Phenotypes associated with this allele

• Allele Symbol: Spo11^tm1Bdm
• Allele Name: targeted mutation 1, Bernard de Massy
• Allele ID: MGI:5432496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spo11^tm1Bdm/Spo11^tm1Bdm	involves: 129	MGI:5523548

Genotype
MGI:5523548

hm1

• Allelic Composition: Spo11^tm1Bdm/Spo11^tm1Bdm
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal meiosis ( J:199075 )

• leptotene and zygotene nuclei display a global absence of double strand break formation and repair

abnormal X-Y chromosome synapsis during male meiosis ( J:199075 )

♂ • a pseudo XY body is present in spermatocytes

abnormal synaptonemal complex ( J:199075 )

• spermatocytes and oocytes reach a zygotene-like stage with variable degrees of heterologous synapsis

abnormal oogenesis ( J:199075 )

♀ • blocked at a zygotene-like stage

arrest of spermatogenesis ( J:199075 )

♂ • blocked at a zygotene-like stage

female infertility ( J:199075 )

♀

male infertility ( J:199075 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:199075 )

♂ • radiation induced double strand breaks elicit a meiotic silencing of unsynapsed chromatin (MSUC) in spermatocytes

cellular

abnormal meiosis ( J:199075 )

• leptotene and zygotene nuclei display a global absence of double strand break formation and repair

abnormal X-Y chromosome synapsis during male meiosis ( J:199075 )

♂ • a pseudo XY body is present in spermatocytes

abnormal synaptonemal complex ( J:199075 )

• spermatocytes and oocytes reach a zygotene-like stage with variable degrees of heterologous synapsis

abnormal oogenesis ( J:199075 )

♀ • blocked at a zygotene-like stage

abnormal double-strand DNA break repair ( J:199075 )

♂ • radiation induced double strand breaks elicit a meiotic silencing of unsynapsed chromatin (MSUC) in spermatocytes