Phenotypes associated with this allele

• Allele Symbol: Calhm1^tm1Geno
• Allele Name: targeted mutation 1, Genoway
• Allele ID: MGI:5432529
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Calhm1^tm1Geno/Calhm1^tm1Geno	involves: 129	MGI:6307102
hm2	Calhm1^tm1Geno/Calhm1^tm1Geno	involves: 129 * C57BL/6	MGI:5432534

Genotype
MGI:6307102

hm1

• Allelic Composition: Calhm1^tm1Geno/Calhm1^tm1Geno
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal gustatory system physiology ( J:269649 )

• type II taste bud cells lack voltage-activated nonselective currents

Genotype
MGI:5432534

hm2

• Allelic Composition: Calhm1^tm1Geno/Calhm1^tm1Geno
• Genetic Background: involves: 129 * C57BL/6

nervous system

abnormal neuron physiology ( J:186424 )

• cortical neurons exhibit altered electrical properties compared with wild-type cells

• following calcium removal and addback, cultured cortical neurons exhibit less robust calcium elevation compared with wild-type cells

• input resistance is completely insensitive to reduction of calcium unlike in wild-type neurons

• reduction of calcium failed to enhance membrane excitability unlike in wild-type neurons

• the current required to maintain -75 mV is larger than in wild-type cortical neurons