Phenotypes associated with this allele

• Allele Symbol: Cpt1c^tm1Fghe
• Allele Name: targeted mutation 1, Fausto G Hegardt
• Allele ID: MGI:5432790
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpt1c^tm1Fghe/Cpt1c^tm1Fghe	B6.129S-Cpt1c^tm1Fghe	MGI:5432792

Genotype
MGI:5432792

hm1

• Allelic Composition: Cpt1c^tm1Fghe/Cpt1c^tm1Fghe
• Genetic Background: B6.129S-Cpt1c^tm1Fghe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:186508 )

• dendritic spines are shorter, more numerous and less mature (mushroom and stubby) compared with spines on wild-type neurons

• however, ceramide treatment rescues spine phenotype

behavior/neurological

abnormal spatial learning ( J:186508 )

• impaired in a Morris water maze with higher escape latency and less time spent in new goal quadrant during reversal testing

homeostasis/metabolism

abnormal lipid level ( J:186508 )

• mice exhibit reduced ceramide levels, including C18:0, in the hippocampus compared with wild-type mice