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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tespa1tm1Smoc
targeted mutation 1, Shanghai Model Organisms Center
MGI:5432877
Summary 6 genotypes


Genotype
MGI:5432916
hm1
Allelic
Composition		 Tespa1tm1Smoc/Tespa1tm1Smoc
Genetic
Background		 B6.129-Tespa1tmSmoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells
increased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells
abnormal thymus morphology ( J:186446 )
• with smaller areas of the medulla compared to in wild-type mice
small thymus medulla ( J:186446 )
• smaller areas of the medulla compared to in wild-type mice
abnormal T cell differentiation ( J:186446 )
• mice exhibit reduced numbers of population 3 and 4 thymocytes due to impaired positive selection compared with wild-type mice
• mice exhibit impaired positive selection of thymocytes expressing MHC class I- or II-restricted T cell receptors compared with wild-type mice
• however, thymocyte proliferation and survival are normal
increased memory T cell number ( J:186446 )
• increased frequency
decreased T cell number ( J:186446 )
• fewer mature T cells in the periphery
decreased CD4-positive, alpha-beta T cell number ( J:186446 )
• in the medulla of the thymus
• in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the medulla of the thymus
• in the spleen
decreased regulatory T cell number ( J:186446 )
• in the thymus and less so in the spleen
decreased interferon-gamma secretion ( J:186446 )
• from CD8+ T cells stimulated with anti-CD3 antibodies
decreased interleukin-2 secretion ( J:186446 )
• from CD8+ T cells stimulated with anti-CD3 antibodies

hematopoietic system
decreased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells
increased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells
abnormal thymus morphology ( J:186446 )
• with smaller areas of the medulla compared to in wild-type mice
small thymus medulla ( J:186446 )
• smaller areas of the medulla compared to in wild-type mice
abnormal T cell differentiation ( J:186446 )
• mice exhibit reduced numbers of population 3 and 4 thymocytes due to impaired positive selection compared with wild-type mice
• mice exhibit impaired positive selection of thymocytes expressing MHC class I- or II-restricted T cell receptors compared with wild-type mice
• however, thymocyte proliferation and survival are normal
increased memory T cell number ( J:186446 )
• increased frequency
decreased T cell number ( J:186446 )
• fewer mature T cells in the periphery
decreased CD4-positive, alpha-beta T cell number ( J:186446 )
• in the medulla of the thymus
• in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the medulla of the thymus
• in the spleen
decreased regulatory T cell number ( J:186446 )
• in the thymus and less so in the spleen

endocrine/exocrine glands
abnormal thymus morphology ( J:186446 )
• with smaller areas of the medulla compared to in wild-type mice
small thymus medulla ( J:186446 )
• smaller areas of the medulla compared to in wild-type mice

cellular
decreased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells
increased T cell proliferation ( J:186446 )
• of splenic CD4+ or CD8+ T cells




Genotype
MGI:5432917
cx2
Allelic
Composition		 Tespa1tm1Smoc/Tespa1tm1Smoc
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 B6.Cg-Tespa1tm1Smoc Tg(TcraTcrb)1100Mjb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus
• in the periphery

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus
• in the periphery




Genotype
MGI:5432918
cx3
Allelic
Composition		 Tespa1tm1Smoc/Tespa1tm1Smoc
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 B6.Cg-Tespa1tm1Smoc Tg(TcraTcrb)425Cbn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:186446 )
• very few cells proceed to the CD4+ single positive stage

hematopoietic system
abnormal T cell differentiation ( J:186446 )
• very few cells proceed to the CD4+ single positive stage




Genotype
MGI:5432920
cx4
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tespa1tm1Smoc/Tespa1tm1Smoc
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:186446 )
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen

hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:186446 )
• unlike in B2mtm1Unc homozygotes, CD8+ single positive thymocytes are detected in the thymus and spleen




Genotype
MGI:5432922
cx5
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tespa1tm1Smoc/Tespa1tm1Smoc
Genetic
Background		 involves: 129 * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (82 available)
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent CD4-positive, alpha-beta T cells ( J:186446 )
• in the thymus compared with H2-Ab1tm1Gru homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus compared with H2-Ab1tm1Gru homozygotes

hematopoietic system
absent CD4-positive, alpha-beta T cells ( J:186446 )
• in the thymus compared with H2-Ab1tm1Gru homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus compared with H2-Ab1tm1Gru homozygotes




Genotype
MGI:5432919
cx6
Allelic
Composition		 Tespa1tm1Smoc/Tespa1tm1Smoc
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tespa1tm1Smoc mutation (1 available); any Tespa1 mutation (33 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus
• in the periphery

immune system
decreased CD8-positive, alpha-beta T cell number ( J:186446 )
• in the thymus
• in the periphery




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory