Phenotypes associated with this allele

• Allele Symbol: Rasgrp4^{tm1d(KOMP)Lste}
• Allele Name: targeted mutation 1d, Len Stephens
• Allele ID: MGI:5432886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasgrp4^tm1d(KOMP)Lste/Rasgrp4^tm1d(KOMP)Lste	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6	MGI:5432889

Genotype
MGI:5432889

hm1

• Allelic Composition: Rasgrp4^{tm1d(KOMP)Lste}/Rasgrp4^{tm1d(KOMP)Lste}
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:186412 )

• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells

• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal

cellular

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal

hematopoietic system

abnormal neutrophil physiology ( J:186412 )

• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells

• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells

impaired neutrophil chemotaxis ( J:186412 )

• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells

• however, migration into an aseptically inflamed peritoneum is normal