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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rasgrp4tm1a(KOMP)Lste
targeted mutation 1a, Len Stephens
MGI:5432887
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rasgrp4tm1a(KOMP)Lste/Rasgrp4tm1a(KOMP)Lste involves: C57BL/6 MGI:5432888


Genotype
MGI:5432888
hm1
Allelic
Composition
Rasgrp4tm1a(KOMP)Lste/Rasgrp4tm1a(KOMP)Lste
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp4tm1a(KOMP)Lste mutation (0 available); any Rasgrp4 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells
• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal

cellular
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal

hematopoietic system
• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells
• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory