About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rasgrp4tm1a(KOMP)Lste
targeted mutation 1a, Len Stephens
MGI:5432887
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rasgrp4tm1a(KOMP)Lste/Rasgrp4tm1a(KOMP)Lste involves: C57BL/6 MGI:5432888


Genotype
MGI:5432888
hm1
Allelic
Composition
Rasgrp4tm1a(KOMP)Lste/Rasgrp4tm1a(KOMP)Lste
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp4tm1a(KOMP)Lste mutation (0 available); any Rasgrp4 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells
• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal

cellular
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal

hematopoietic system
• across all times of stimulation and doses of agonist, neutrophils exhibit reduced reactive oxygen species production compared with wild-type cells
• PMA-stimulated neutrophils exhibit increased reactive oxygen species production compared with wild-type cells
• fewer neutrophils migrate on glass and fibrinogen-coated glass in response to fMLP compared with wild-type cells
• however, migration into an aseptically inflamed peritoneum is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory