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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrp4tm1(cre)Rls
targeted mutation 1, Richard L Stevens
MGI:5432899
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasgrp4tm1(cre)Rls/Rasgrp4tm1(cre)Rls C57BL/6-Rasgrp4tm1(cre)Rls MGI:5432911


Genotype
MGI:5432911
hm1
Allelic
Composition		 Rasgrp4tm1(cre)Rls/Rasgrp4tm1(cre)Rls
Genetic
Background		 C57BL/6-Rasgrp4tm1(cre)Rls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp4tm1(cre)Rls mutation (0 available); any Rasgrp4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced colitis ( J:186519 )
• DSS-treated mice exhibit reduced colitis with less weight loss, longer colons and lower histopathology scores compared with wild-type mice
decreased susceptibility to induced arthritis ( J:186519 )
• mice treated with serum from a K/BxN mouse fail to develop arthritis without accelerated clearance of autoantibodies unlike wild-type mice

digestive/alimentary system
decreased susceptibility to induced colitis ( J:186519 )
• DSS-treated mice exhibit reduced colitis with less weight loss, longer colons and lower histopathology scores compared with wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:186519 )
• mice treated with serum from a K/BxN mouse fail to develop arthritis without accelerated clearance of autoantibodies unlike wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory