All Phenotypes Fezf2<tm1.1Nses> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fezf2^tm1.1Nses
targeted mutation 1.1, Nenad Sestan
MGI:5433045

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Emx1^tm1(cre)Ito/Emx1⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:5433183
cn2	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Tbr1^tm1Jlr/Tbr1^tm1Jlr Tg(Emx1-cre)#Ito/0 Tg(Mbp-MAPT/EGFP)#Eja/0	involves: 129S1/Sv * C57BL/6	MGI:5433181
cn3	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Tg(CAG-cat,-EGFP)39Miya/0 Tg(Emx1-cre)#Ito/0	involves: 129S1/Sv * C57BL/6 * C57BL/6NJcl * DBA/2NJcl	MGI:5433180

Allelic Composition	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Emx1^tm1(cre)Ito/Emx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Fezf2^tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corticospinal tract morphology ( J:186632 )

• mice lack corticospinal axons in the pons

Allelic Composition	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Tbr1^tm1Jlr/Tbr1^tm1Jlr Tg(Emx1-cre)#Ito/0 Tg(Mbp-MAPT/EGFP)#Eja/0
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2^tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
Tbr1^tm1Jlr mutation (1 available); any Tbr1 mutation (38 available)
Tg(Emx1-cre)#Ito mutation (0 available)
Tg(Mbp-MAPT/EGFP)#Eja mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Aberrant L6 projections to the brainstem in the Tbr1^tm1Jlr/Tbr1^tm1Jlr mice require Fezf2

nervous system

nervous system phenotype ( J:169221 )

N	• unlike Tbr1^tm1Jlr homozygotes, mice lack retrograde labeling of L5 and L6 projection neurons

Allelic Composition	Fezf2^tm1.1Nses/Fezf2^tm1.1Nses Tg(CAG-cat,-EGFP)39Miya/0 Tg(Emx1-cre)#Ito/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2^tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
Tg(CAG-cat,-EGFP)39Miya mutation (1 available)
Tg(Emx1-cre)#Ito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corticospinal tract morphology ( J:169221 )

• mice lack corticospinal axons in the brainstem

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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