All Phenotypes Tmem107<schlei> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem107^schlei/Tmem107^schlei	C3Fe.B6-Tmem107^schlei	MGI:5433091
ht2	Tmem107^schlei/Tmem107^tm1Lex	involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N	MGI:5433098
cx3	Ptch1^tm1Mps/Ptch1^tm1Mps Tmem107^schlei/Tmem107^schlei	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:5433092
cx4	Shh^tm1Chg/Shh^tm1Chg Tmem107^schlei/Tmem107^schlei	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J	MGI:5433094
cx5	Gli2^tm2.1Alj/Gli2^tm2.1Alj Tmem107^schlei/Tmem107^schlei	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J	MGI:5433095
cx6	Smo^bnb/Smo^bnb Tmem107^schlei/Tmem107^schlei	involves: C3HeB/FeJ * C57BL/6J	MGI:5433093
cx7	Gli3^Xt-J/Gli3^Xt-J Tmem107^schlei/Tmem107^schlei	involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J	MGI:5433096

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:186552 )

• Background Sensitivity: continued crossing into the C3HeB/FeJ background reduces survival into late embryonic stages

craniofacial

abnormal basioccipital bone morphology ( J:186552 )

• some mice exhibit precocious fusion between the basioccipital and exoccipital bones

basisphenoid bone foramen ( J:186552 )

• in some mice

small basisphenoid bone ( J:186552 )

• in some mice

abnormal exoccipital bone morphology ( J:186552 )

• some mice exhibit precocious fusion between the basioccipital and exoccipital bones

absent presphenoid bone ( J:186552 )

• in some mice

short presphenoid bone ( J:186552 )

• in some mice

palatal shelf hypoplasia ( J:186552 )

• in some mice

cleft palate ( J:186552 )

• in some mice

limbs/digits/tail

ectopic digits ( J:186552 )

• most mutant limbs exhibit at least one ectopic digit

preaxial polydactyly ( J:186552 )

camptomelia ( J:186552 )

• some mice exhibit bowing in the zeugopod bones of the forelimbs and hindlimbs

abnormal limb development ( J:186552 )

• limb mesenchyme exhibit reduced number of cilia compared to in wild-type mice

broad limb buds ( J:186552 )

• broadening of limbs at E12.5 in the anteroposterior axis

nervous system

abnormal neural tube morphology ( J:186552 )

• the lining of the neural tube lumen exhibits reduced number of cilia compared to in wild-type mice

• the neural tube lining exhibits bulges, long curled cilia unlike in wild-type mice

• mice exhibit defective neuronal patterning at the hind limb level of the neural tube

absent floor plate ( J:186552 )

exencephaly ( J:186552 )

• in some mice

vision/eye

microphthalmia ( J:186552 )

• in some mice

cellular

abnormal cilium morphology ( J:186552 )

• mouse embryonic fibroblasts exhibit reduced cilia number compared with wild-type cells

digestive/alimentary system

palatal shelf hypoplasia ( J:186552 )

• in some mice

cleft palate ( J:186552 )

• in some mice

embryo

embryo phenotype ( J:186552 )

N	• mice do not develop left-right patterning defects and the cilia in the embryonic node are normal

broad limb buds ( J:186552 )

• broadening of limbs at E12.5 in the anteroposterior axis

abnormal neural tube morphology ( J:186552 )

• the lining of the neural tube lumen exhibits reduced number of cilia compared to in wild-type mice

• the neural tube lining exhibits bulges, long curled cilia unlike in wild-type mice

• mice exhibit defective neuronal patterning at the hind limb level of the neural tube

absent floor plate ( J:186552 )

liver/biliary system

liver/biliary system phenotype ( J:186552 )

N	• at E18.5, mice do not display obvious kidney or liver cysts

renal/urinary system

renal/urinary system phenotype ( J:186552 )

N	• at E18.5, mice do not display obvious kidney or liver cysts

skeleton

abnormal basioccipital bone morphology ( J:186552 )

• some mice exhibit precocious fusion between the basioccipital and exoccipital bones

basisphenoid bone foramen ( J:186552 )

• in some mice

small basisphenoid bone ( J:186552 )

• in some mice

abnormal exoccipital bone morphology ( J:186552 )

• some mice exhibit precocious fusion between the basioccipital and exoccipital bones

absent presphenoid bone ( J:186552 )

• in some mice

short presphenoid bone ( J:186552 )

• in some mice

camptomelia ( J:186552 )

• some mice exhibit bowing in the zeugopod bones of the forelimbs and hindlimbs

short sternum ( J:186552 )

• in some mice

split sternum ( J:186552 )

• in some mice

rib bifurcation ( J:186552 )

• in some mice

delayed intramembranous bone ossification ( J:186552 )

• some mice exhibit reduced ossification of the frontal, parietal and interparietal bones

growth/size/body

palatal shelf hypoplasia ( J:186552 )

• in some mice

cleft palate ( J:186552 )

• in some mice

Allelic Composition	Tmem107^schlei/Tmem107^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)
Tmem107^tm1Lex mutation (3 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent floor plate ( J:186552 )

• at E10.5

limbs/digits/tail

preaxial polydactyly ( J:186552 )

• at E13.5

embryo

absent floor plate ( J:186552 )

• at E10.5

Allelic Composition	Ptch1^tm1Mps/Ptch1^tm1Mps Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube closure ( J:186552 )

• neural tube closure defects observed in Ptch1^tm1Mps homozygotes are partially rescued

exencephaly ( J:186552 )

growth/size/body

decreased embryo size ( J:186552 )

• reduced embryo size observed in Ptch1^tm1Mps homozygotes is partially rescued

abnormal head morphology ( J:186552 )

• head formation defects observed in Ptch1^tm1Mps homozygotes are partially rescued

embryo

decreased embryo size ( J:186552 )

• reduced embryo size observed in Ptch1^tm1Mps homozygotes is partially rescued

abnormal neural tube closure ( J:186552 )

• neural tube closure defects observed in Ptch1^tm1Mps homozygotes are partially rescued

Allelic Composition	Shh^tm1Chg/Shh^tm1Chg Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (46 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• however, ventral neuron specification defects of V2 interneurons and motor neurons observed in Smo^bnb homozygotes is partially rescued

exencephaly ( J:186552 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:186552 )

N	• increased apoptosis observed in the limb bud of Smo^bnb homozygotes is rescued

oligodactyly ( J:186552 )

• reduced digit number observed in Smo^bnb homozygotes is rescued to four or five digits

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• however, ventral neuron specification defects of V2 interneurons and motor neurons observed in Smo^bnb homozygotes is partially rescued

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm2.1Alj Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:186552 )

• mice exhibit loss of floor plate cells and V3 interneurons

• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107^schlei homozygotes is blocked

nervous system

abnormal floor plate morphology ( J:186552 )

• mice exhibit loss of floor plate cells and V3 interneurons

• however, dorsal expansion of V2 interneuron progenitors observed in Tmem107^schlei homozygotes is blocked

Allelic Composition	Smo^bnb/Smo^bnb Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smo^bnb mutation (0 available); any Smo mutation (39 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• Background Sensitivity: however, ventral neuron specification defects observed in Smo^bnb homozygotes is partially rescued

exencephaly ( J:186552 )

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• Background Sensitivity: however, ventral neuron specification defects observed in Smo^bnb homozygotes is partially rescued

Allelic Composition	Gli3^Xt-J/Gli3^Xt-J Tmem107^schlei/Tmem107^schlei
Genetic Background	involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^Xt-J mutation (3 available); any Gli3 mutation (80 available)
Tmem107^schlei mutation (0 available); any Tmem107 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• dorsal expansion of motor neuron progenitors and V2 interneuron progenitors observed in Tmem107^schlei homozygotes is exacerbated

nervous system

abnormal floor plate morphology ( J:186552 )

• absence of ventral cell types (V3) in the floor plate

• dorsal expansion of motor neuron progenitors and V2 interneuron progenitors observed in Tmem107^schlei homozygotes is exacerbated

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