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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp4tm2.1Eem
targeted mutation 2.1, Edward E Morrisey
MGI:5433099
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433105
cn2
Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433106
cn3
Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433107


Genotype
MGI:5433105
cn1
Allelic
Composition
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal prenatal and postnatal survival




Genotype
MGI:5433106
cn2
Allelic
Composition
Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within minutes of birth of apparent respiratory distress

respiratory system
• in the proximal airways at E18.5
• as determined by marker expression, mice exhibit an increase in ciliated epithelial cell differentiation compared with control mice




Genotype
MGI:5433107
cn3
Allelic
Composition
Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Scgb1a1tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice exhibit an increase in goblet cell differentiation compared with control mice
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory