About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp4tm2.1Eem
targeted mutation 2.1, Edward E Morrisey
MGI:5433099
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433105
cn2
 		Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433106
cn3
 		Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5433107


Genotype
MGI:5433105
cn1
Allelic
Composition		 Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:185603 )
N
• mice exhibit normal prenatal and postnatal survival




Genotype
MGI:5433106
cn2
Allelic
Composition		 Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:185603 )
• mice die within minutes of birth of apparent respiratory distress

respiratory system
decreased club cell number ( J:185603 )
• in the proximal airways at E18.5
abnormal respiratory system development ( J:185603 )
• as determined by marker expression, mice exhibit an increase in ciliated epithelial cell differentiation compared with control mice




Genotype
MGI:5433107
cn3
Allelic
Composition		 Foxp1tm1.1Pwt/Foxp1tm1.1Pwt
Foxp4tm2.1Eem/Foxp4tm2.1Eem
Scgb1a1tm1(icre)Fjd/Scgb1a1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp1tm1.1Pwt mutation (1 available); any Foxp1 mutation (77 available)
Foxp4tm2.1Eem mutation (0 available); any Foxp4 mutation (91 available)
Scgb1a1tm1(icre)Fjd mutation (1 available); any Scgb1a1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system development ( J:185603 )
• mice exhibit an increase in goblet cell differentiation compared with control mice
abnormal respiratory system physiology ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice

homeostasis/metabolism
increased susceptibility to injury ( J:185603 )
• following naphthalene injury, mice exhibit defective epithelial regeneration by ectopically activating goblet cell fate compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory