Analysis Tools
cardiovascular system
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• myocyte cross sectional area shows limited increase after two weeks of transverse aortic constriction but significantly greater increase in length
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• more of the myocardium is covered by collagen than in controls
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• thickness is increased after two weeks of transverse aortic constriction more than in controls
• wall stress elevated
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• less hypertrophy develops after two weeks of transverse aortic constriction than in controls
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• end-diastolic diameter is increased after two weeks of transverse aortic constriction more than in controls
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• ejection fraction is reduced after two weeks of transverse aortic constriction
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• end-diastolic pressure elevated after two weeks of transverse aortic constriction more than in controls
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mortality/aging
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• mortality rate during transverse aortic constriction is double that of controls
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respiratory system
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• lung weight/tibia weight ratio is increased after two weeks of transverse aortic constriction
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cellular
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• ADP/oxygen and respiratory control ratio of mitochondria are significantly reduced relative to controls
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immune system
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• plasma IL6 levels are reduced under basal conditions
• transverse aortic constriction causes further reduction in IL6 levels
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muscle
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• more of the myocardium is covered by collagen than in controls
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• ejection fraction is reduced after two weeks of transverse aortic constriction
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homeostasis/metabolism
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• plasma IL6 levels are reduced under basal conditions
• transverse aortic constriction causes further reduction in IL6 levels
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growth/size/body
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• less hypertrophy develops after two weeks of transverse aortic constriction than in controls
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• lung weight/tibia weight ratio is increased after two weeks of transverse aortic constriction
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