Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Emx1-cre)#Ito transgene insertion, Shigeyoshi Itohara MGI:5433170 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal activity levels and a trend for decreased head tracking
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal activity levels and a trend for decreased head tracking
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Aberrant L6 projections to the brainstem in the Tbr1tm1Jlr/Tbr1tm1Jlr mice require Fezf2
| N |
• unlike Tbr1tm1Jlr homozygotes, mice lack retrograde labeling of L5 and L6 projection neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice lack corticospinal axons in the brainstem
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show reduced alternation in the Y-maze at P21 and 3 months, suggesting poor short-term memory
• however, mice show normal behavior in the elevated plus maze
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• mice spend less time grooming at P21
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• mice exhibit increased immobility time in the open field test at P21
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• neuronal mitochondrial volume and branch number are reduced in the cell body of neurons
• mitochondrial abnormalities are seen with higher frequency in small mitochondria than large mitochondria
• cardiolipin is reduced in mitochondria isolated from brains, however no differences are seen for other phospholipids
• however, mitochondrial swelling is absent and enhanced autophagy or mitophagy is not seen
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• neuronal mitochondria shows numerous dilated, swollen cristae
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• neuronal mitochondria shows empty matrices
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• small and simple structured mitochondria are dominant in neurons, while large branched mitochondria are scarcely detected
• small mitochondria are also seen in astrocytes
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• level of oxidized proteins is enhanced in the hippocampus indicating enhanced oxidative stress in neurons
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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• nearly all cardiolipin species are reduced in the brain
• cardiolipin is reduced in mitochondria isolated from brains
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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• mice show enhanced microglial activation in the cerebral cortex and hippocampus
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• mice show enhanced astrogliosis in the cerebral cortex and hippocampus
• treatment with a radical scavenger Edaravone attenuates astrogliosis
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• increase in small mitochondria in neurons and loss of large and branched mitochondria
• neurons show reduced endoplasmic reticulum (ER)-mitochondria contact sites; reduction in both total area and the number of ER-mitochondria contact sites and the frequency of ER-mitochondria contact, indicating reduced ER tethering to mitochondria
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• immature dentate gyrus with decreased mature neuron numbers
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• decreased mature neurons in the dentate gyrus
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• at P21 and 8 weeks without increased anxiety
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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