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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mbp-MAPT/EGFP)#Eja
transgene insertion, Erin C Jacobs
MGI:5433179
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Emx1-cre)#Ito/0
Tg(Mbp-MAPT/EGFP)#Eja/0 		involves: 129S1/Sv * C57BL/6 MGI:5433181
cx2
 		Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Mbp-MAPT/EGFP)#Eja/0 		involves: 129X1/SvJ MGI:5433182


Genotype
MGI:5433181
cn1
Allelic
Composition		 Fezf2tm1.1Nses/Fezf2tm1.1Nses
Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Emx1-cre)#Ito/0
Tg(Mbp-MAPT/EGFP)#Eja/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf2tm1.1Nses mutation (1 available); any Fezf2 mutation (49 available)
Tbr1tm1Jlr mutation (1 available); any Tbr1 mutation (38 available)
Tg(Emx1-cre)#Ito mutation (0 available)
Tg(Mbp-MAPT/EGFP)#Eja mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Aberrant L6 projections to the brainstem in the Tbr1tm1Jlr/Tbr1tm1Jlr mice require Fezf2

nervous system
nervous system phenotype ( J:169221 )
N
• unlike Tbr1tm1Jlr homozygotes, mice lack retrograde labeling of L5 and L6 projection neurons




Genotype
MGI:5433182
cx2
Allelic
Composition		 Tbr1tm1Jlr/Tbr1tm1Jlr
Tg(Mbp-MAPT/EGFP)#Eja/0
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbr1tm1Jlr mutation (1 available); any Tbr1 mutation (38 available)
Tg(Mbp-MAPT/EGFP)#Eja mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Premature overgrowth and superabundance of subcortical axons in the brainstem of Tbr1tm1Jlr/Tbr1tm1Jlr Tg(Mbp-MAPT/EGFP)#Eja/0 mice

nervous system
abnormal innervation ( J:169221 )
• mice exhibit ectopic projections to the brainstem identified by retrograde tracing




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory