Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgf13tm1Xuzh targeted mutation 1, Xu Zhang MGI:5433221 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice
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• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit impaired hippocampal development compared with wild-type mice
• however, positioning of hippocampal neurons is normal by P30
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• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
• the dentate gyrus exhibit increased neuron numbers in the polymorphic layer compared with in wild-type mice
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• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
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• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells
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• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
• mice exhibit more loosely arrayed neurons with irregular inner and outer borders in the C1 pyramidal layer compared to in wild-type mice
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• reduced Cux1+ cells
• however, the number of Cux1+ neurons are normal at P14 and during adulthood
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• Tbr1+ neurons in the deep layer is increased compared to in wild-type mice
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• in a Morris water maze
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• in a Morris water maze
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a Morris water maze
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• in a Morris water maze
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• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired
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• in a Morris water maze
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• in a Morris water maze
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• increased depression-like behavior
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• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
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• slight
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• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
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• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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