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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf13tm1Xuzh
targeted mutation 1, Xu Zhang
MGI:5433221
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fgf13tm1Xuzh/Fgf13tm1Xuzh involves: 129 MGI:5433297
cn2
 		Fgf13tm1Xuzh/Y
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129 * FVB/N MGI:5433298
cn3
 		Fgf13tm1Xuzh/Fgf13tm1Xuzh
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129 * FVB/N MGI:5433299
cn4
 		Fgf13tm1Xuzh/Y
Emx1tm1(cre)Yql/Emx1+ 		involves: 129S2/SvPas MGI:5433296


Genotype
MGI:5433297
cn1
Allelic
Composition		 Fgf13tm1Xuzh/Fgf13tm1Xuzh
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation (0 available); any Fgf13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal neuronal migration ( J:186253 )
• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice

nervous system
abnormal neuronal migration ( J:186253 )
• following electroporation with cre recombinase at E14.5, cortical neurons exhibit impaired migration at E18 and P0 compared to in control mice




Genotype
MGI:5433298
cn2
Allelic
Composition		 Fgf13tm1Xuzh/Y
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation (0 available); any Fgf13 mutation (12 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus morphology ( J:186253 )
• mice exhibit impaired hippocampal development compared with wild-type mice
• however, positioning of hippocampal neurons is normal by P30
abnormal dentate gyrus morphology ( J:186253 )
• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
• the dentate gyrus exhibit increased neuron numbers in the polymorphic layer compared with in wild-type mice
abnormal cerebellar granule cell morphology ( J:186253 )
• mice exhibit loosely packed neurons in the granule cell layer of the dentrate gyrus compared with wild-type mice
abnormal neuron morphology ( J:186253 )
• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells
abnormal cerebral cortex pyramidal cell morphology ( J:186253 )
• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
• mice exhibit more loosely arrayed neurons with irregular inner and outer borders in the C1 pyramidal layer compared to in wild-type mice
decreased neuron number ( J:186253 )
• reduced Cux1+ cells
• however, the number of Cux1+ neurons are normal at P14 and during adulthood
increased neuron number ( J:186253 )
• Tbr1+ neurons in the deep layer is increased compared to in wild-type mice

behavior/neurological
abnormal spatial learning ( J:186253 )
• in a Morris water maze
abnormal spatial working memory ( J:186253 )
• in a Morris water maze




Genotype
MGI:5433299
cn3
Allelic
Composition		 Fgf13tm1Xuzh/Fgf13tm1Xuzh
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf13tm1Xuzh mutation (0 available); any Fgf13 mutation (12 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:186253 )
• in a Morris water maze
abnormal spatial working memory ( J:186253 )
• in a Morris water maze

nervous system
abnormal neuron morphology ( J:186253 )
• neurons exhibit impaired stabilization of microtubule organization in growth cones compared with wild-type cells




Genotype
MGI:5433296
cn4
Allelic
Composition		 Fgf13tm1Xuzh/Y
Emx1tm1(cre)Yql/Emx1+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Fgf13tm1Xuzh mutation (0 available); any Fgf13 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:186253 )
• in a Morris water maze
abnormal spatial working memory ( J:186253 )
• in a Morris water maze
abnormal depression-related behavior ( J:186253 )
• increased depression-like behavior
increased anxiety-related response ( J:186253 )
• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
hyperactivity ( J:186253 )
• slight

nervous system
abnormal cerebral cortex pyramidal cell morphology ( J:186253 )
• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
abnormal axon morphology ( J:186253 )
• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory