Phenotypes associated with this allele

• Allele Symbol: Tg(Crx-Atoh7,-cre)60Gla
• Allele Name: transgene insertion 60, Tom Glaser
• Allele ID: MGI:5433290
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atoh7^tm1Gla/Atoh7^tm1Gla Tg(Crx-Atoh7,-cre)60Gla/0 Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor^+	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL	MGI:5433338

Genotype
MGI:5433338

cn1

• Allelic Composition: Atoh7^tm1Gla/Atoh7^tm1Gla; Tg(Crx-Atoh7,-cre)60Gla/0; Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal optic nerve innervation ( J:186563 )

• knots of retinal ganglion cell axons are observed, consistent with the small degree of rescue

abnormal retina nerve fiber layer morphology ( J:186563 )

• the BAC Crx-Atoh7 (Crx-Math5) construct shows some rescue of retinal axons and prevention of fasciculation defects in double mutants compared to Atoh7 homozygotes; level of rescue is lower than that seen in Atoh7-null homozygotes crossed to the conventional transgenic Atoh7 mice (Tg(Crx-Atoh7,-cre)251Gla)

• rescue is less pronounced with successive generations

nervous system

abnormal optic nerve innervation ( J:186563 )

• knots of retinal ganglion cell axons are observed, consistent with the small degree of rescue