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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlx3tm2.1Qima
targeted mutation 2.1, Qiufu Ma
MGI:5433363
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tlx3tm2.1Qima/Tlx3tm2.1Qima
Tg(Scn10a-cre)1Rkun/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 * SJL MGI:5433368


Genotype
MGI:5433368
cn1
Allelic
Composition		 Tlx3tm2.1Qima/Tlx3tm2.1Qima
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scn10a-cre)1Rkun mutation (0 available)
Tlx3tm2.1Qima mutation (0 available); any Tlx3 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:186470 )
• at P30 lumbar in the dorsal root ganglion the molecular identity of IB4+ neurons is modified resulting in impaired segregation of TrkA+ and Ret+ neurons
• decrease or absence of expression of genes encoding sensory channels and receptors involved with pain, itch and/or temperature sensation at P30 in the lumbar and thoracic dorsal root ganglia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory