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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc5a1tm1.1Koep
targeted mutation 1.1, Hermann Koepsell
MGI:5433400
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc5a1tm1.1Koep/Slc5a1tm1.1Koep B6.129P2-Slc5a1tm1.1Koep MGI:5433498


Genotype
MGI:5433498
hm1
Allelic
Composition
Slc5a1tm1.1Koep/Slc5a1tm1.1Koep
Genetic
Background
B6.129P2-Slc5a1tm1.1Koep
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc5a1tm1.1Koep mutation (0 available); any Slc5a1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die 2 days after weaning when they receive a standard diet
• mice fed a glucose-galactose-free diet then transferred to standard chow die within 7 to 12 days
• however, mice fed a diet lacking free monosaccharides and disaccharides exhibit normal survival

homeostasis/metabolism
• after glucose gavage
• mice exhibit reduced glucose triggered glucose-induced secretion of insulintropic hormone and glucagon-like peptide compared with wild-type mice
• after glucose gavage
• mice exhibit reduced renal proximal tubule reabsorption of filtered D-glucose compared with wild-type mice

digestive/alimentary system
• mice fed a standard diet exhibit distended small and large intestines unlike wild-type mice
• mice fed a standard diet exhibit distended small and large intestines unlike wild-type mice
• phlorizin-inhibitable uptake of glucose is inhibited in the brush border membrane of the small intestine compared with wild-type mice
• sodium-D-glucose co-transport across the small intestinal brush border membrane is absent

renal/urinary system
• mice exhibit reduced renal proximal tubule reabsorption of filtered D-glucose compared with wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory