Phenotypes associated with this allele

• Allele Symbol: Hey2^tm2.1Mtc
• Allele Name: targeted mutation 2.1, Michael T Chin
• Allele ID: MGI:5433499
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hey2^tm2.1Mtc/Hey2^tm2.1Mtc Tg(Myh6-cre)2182Mds/0	involves: C57BL/6 * FVB/N * SJL	MGI:5433520

Genotype
MGI:5433520

cn1

• Allelic Composition: Hey2^tm2.1Mtc/Hey2^tm2.1Mtc; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiac hypertrophy ( J:186570 )

• after pressure overload

cardiac fibrosis ( J:186570 )

• after pressure overload

decreased cardiac muscle contractility ( J:186570 )

• after pressure overload

• in cells from 12 week old mice

• however, treatment with FK506, an inhibitor of FKBP12.6, rescues defective cardiac function

abnormal myocardial fiber physiology ( J:186570 )

• cardiomyocytes exhibit altered calcium cycling compared with control mice

• however, calcium sensitivity and stores are normal and treatment with FK506, an inhibitor of FKBP12.6, rescues defective peak calcium release

increased response of heart to induced stress ( J:186570 )

• after pressure overload, mice exhibit increased cardiac hypertrophy, decreased fractional shortening, fibrosis and heart failure compared with control mice

congestive heart failure ( J:186570 )

• after pressure overload

• however, mice do not exhibit cardiac failure under normal conditions

homeostasis/metabolism

increased response of heart to induced stress ( J:186570 )

• after pressure overload, mice exhibit increased cardiac hypertrophy, decreased fractional shortening, fibrosis and heart failure compared with control mice

muscle

decreased cardiac muscle contractility ( J:186570 )

• after pressure overload

• in cells from 12 week old mice

• however, treatment with FK506, an inhibitor of FKBP12.6, rescues defective cardiac function

growth/size/body

cardiac hypertrophy ( J:186570 )

• after pressure overload