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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esr1tm1.1Gust
targeted mutation 1.1, Jan-Ake Gustafsson
MGI:5433576
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Esr1tm1.1Gust/Esr1tm1.1Gust B6.129X1-Esr1tm1.1Gust MGI:5433577


Genotype
MGI:5433577
hm1
Allelic
Composition		 Esr1tm1.1Gust/Esr1tm1.1Gust
Genetic
Background		 B6.129X1-Esr1tm1.1Gust
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Gust mutation (1 available); any Esr1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
ovary hemorrhage ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age
ovary cyst ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age
uterus hypoplasia ( J:186230 )
• rudimentary at 10 weeks of age and severely hypoplastic at 1 year of age

growth/size/body
ovary cyst ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age
increased body weight ( J:186230 )
• significant in females at 4 months of age and increases with age
obese ( J:186230 )
• females

homeostasis/metabolism
increased circulating glucose level ( J:186230 )
• basal blood levels are increased in females

cardiovascular system
ovary hemorrhage ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

endocrine/exocrine glands
ovary hemorrhage ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age
abnormal mammary gland development ( J:186230 )
• ductal elongation fails to reach the lymph nodes at 7 weeks of age
ovary cyst ( J:186230 )
• hemorrhagic polycystic ovaries at 10 weeks of age that become more severe at 1 year of age

integument
abnormal mammary gland development ( J:186230 )
• ductal elongation fails to reach the lymph nodes at 7 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory