All Phenotypes Tg(Csf1r-cre/Esr1*)1Jwp MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Csf1r-cre/Esr1*)1Jwp
transgene insertion 1, Jeffrey W Pollard
MGI:5433683

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Vegfa^tm2Gne/Vegfa^tm2Gne Tg(Csf1r-cre/Esr1*)1Jwp/0	involves: 129 * C57BL/6 * FVB/N	MGI:5435892

Allelic Composition	Vegfa^tm2Gne/Vegfa^tm2Gne Tg(Csf1r-cre/Esr1*)1Jwp/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Csf1r-cre/Esr1*)1Jwp mutation (1 available)
Vegfa^tm2Gne mutation (2 available); any Vegfa mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:186831 )

• after tamoxifen-induced recombination to ablate Vegfa in cultured bone marrow-derived macrophages, the BMDMs are unable to promote trans-endothelial migration of tumor cells or enhance permeability of the endothelial monolayer, both important for metastasis

• adoptive transfer of Vegfa-null monocytes infiltrate lung metastases comparably to wild-type inflammatory monocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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