Phenotypes associated with this allele

• Allele Symbol: Cripto^tm1.1Gmin
• Allele Name: targeted mutation 1.1, Gabriella Minchiotti
• Allele ID: MGI:5433707
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cripto^tm1.1Gmin/Cripto^tm1.1Gmin	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433708

Genotype
MGI:5433708

hm1

• Allelic Composition: Cripto^tm1.1Gmin/Cripto^tm1.1Gmin
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Arrested development in Cripto^tm1.1Gmin/Cripto^tm1.1Gmin embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:186907 )

• die between E10.5 and E11.5

embryo

abnormal developmental patterning ( J:186907 )

• Nodal signaling is impaired

abnormal gastrulation ( J:186907 )

abnormal embryo turning ( J:186907 )

• fail to turn at E8.5

embryonic growth arrest ( J:186907 )

• arrest after initiation of gastrulation

abnormal embryonic tissue morphology ( J:186907 )

• ectopic folds in the embryonic region at E7.5

• unlike in null mice, the A-P axis is established

abnormal neural fold morphology ( J:186907 )

• enlarged at E8.5

absent somites ( J:186907 )

• at E8.5

cardiovascular system

abnormal heart morphology ( J:186907 )

• absence of a beating heart at E8.5