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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga2tm1.1Tkun
targeted mutation 1.1, Thomas Kunicki
MGI:5433752
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itga2tm1.1Tkun/Itga2tm1.1Tkun B6.Cg-Itga2tm1.1Tkun/J MGI:5435923
cn2
 		Itga2tm1.1Tkun/Itga2tm1.1Tkun
Tg(Pf4-icre)Q3Rsko/0 		involves: C57BL/6 * SJL MGI:5496813


Genotype
MGI:5435923
hm1
Allelic
Composition		 Itga2tm1.1Tkun/Itga2tm1.1Tkun
Genetic
Background		 B6.Cg-Itga2tm1.1Tkun/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1.1Tkun mutation (1 available); any Itga2 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:186912 )
• viable and fertile




Genotype
MGI:5496813
cn2
Allelic
Composition		 Itga2tm1.1Tkun/Itga2tm1.1Tkun
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2tm1.1Tkun mutation (1 available); any Itga2 mutation (80 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet physiology ( J:195799 )
• platelets exhibit reduced adhesion and aggregation in response to soluble collagen compared with control cells
• however, tail bleeding times are normal
decreased platelet aggregation ( J:195799 )
• in response to soluble collagen

homeostasis/metabolism
abnormal platelet physiology ( J:195799 )
• platelets exhibit reduced adhesion and aggregation in response to soluble collagen compared with control cells
• however, tail bleeding times are normal
decreased platelet aggregation ( J:195799 )
• in response to soluble collagen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory