Phenotypes associated with this allele

• Allele Symbol: Xdh^renf
• Allele Name: Renal Failure
• Allele ID: MGI:5435289
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xdh^renf/Xdh^renf	involves: C3H * C57BL/6J	MGI:5435300

Genotype
MGI:5435300

hm1

• Allelic Composition: Xdh^renf/Xdh^renf
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:187066 )

• fail to thrive and do not live beyond 5-9 weeks

growth/size/body

slow postnatal weight gain ( J:187066 )

• although weight is similar to controls at birth, weight is 23% less at 3 weeks of age

renal/urinary system

abnormal kidney cortex morphology ( J:187066 )

• uneven distribution of glomeruli and tubules in the cortex

renal interstitial fibrosis ( J:187066 )

small kidney ( J:187066 )

• at 4 weeks of age

• irregularly shaped

abnormal renal tubule morphology ( J:187066 )

• tubular cell damage

• tubules sometimes detatched from basement membrane

abnormal renal tubule epithelium morphology ( J:187066 )

• extensive apoptosis of tubular epithelium cells

dilated renal tubule ( J:187066 )

homeostasis/metabolism

increased circulating creatinine level ( J:187066 )

increased blood urea nitrogen level ( J:187066 )

decreased blood uric acid level ( J:187066 )

• undetectable

increased circulating calcium level ( J:187066 )

increased circulating alkaline phosphatase level ( J:187066 )

• increased alkaline phosphatase activity

endocrine/exocrine glands

increased activity of parathyroid ( J:187066 )