All Phenotypes Phex<Hpr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Phex^Hpr
hypophosphatemic rickets
MGI:5435304

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Phex^Hpr/Phex⁺	involves: C3H/HeH * C57BL/6J	MGI:5435551
ot2	Phex^Hpr/Y	involves: C3H/HeH * C57BL/6J	MGI:5435550

Allelic Composition	Phex^Hpr/Phex⁺
Genetic Background	involves: C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phex^Hpr mutation (2 available); any Phex mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal long bone morphology ( J:187142 )

• heterozygous female mice with bowed tibia

increased diameter of femur ( J:187142 )

• increased mid femoral diaphysis diameter by 17%

decreased length of long bones ( J:187142 )

short femur ( J:187142 )

• reduced more than 10%

abnormal vertebrae morphology ( J:187142 )

• vertebral height reduced by 15%

abnormal bone structure ( J:187142 )

• increased bone porosity at all ages

decreased bone mineral density ( J:187142 )

• at 20 weeks of age

homeostasis/metabolism

decreased circulating phosphate level ( J:187142 )

• at 12 weeks of age

increased circulating alkaline phosphatase level ( J:187142 )

• at 12 weeks of age

limbs/digits/tail

short femur ( J:187142 )

• reduced more than 10%

increased diameter of femur ( J:187142 )

• increased mid femoral diaphysis diameter by 17%

Allelic Composition	Phex^Hpr/Y
Genetic Background	involves: C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phex^Hpr mutation (2 available); any Phex mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

short femur ( J:187142 )

• reduced more than 10%

increased diameter of femur ( J:187142 )

• increased mid femoral diaphysis diameter by 17%

abnormal vertebrae morphology ( J:187142 )

• vertebral height reduced by 15%

abnormal bone structure ( J:187142 )

• increased bone porosity at all ages

decreased bone mineral density ( J:187142 )

• at 20 weeks of age

homeostasis/metabolism

decreased circulating phosphate level ( J:187142 )

• at 12 weeks of age

increased circulating alkaline phosphatase level ( J:187142 )

• at 12 weeks of age

limbs/digits/tail

short femur ( J:187142 )

• reduced more than 10%

increased diameter of femur ( J:187142 )

• increased mid femoral diaphysis diameter by 17%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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