Phenotypes associated with this allele

• Allele Symbol: Slc8a1^tm1Herc
• Allele Name: targeted mutation 1, Andre Herchuelz
• Allele ID: MGI:5436242
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc8a1^tm1Herc/Slc8a1^tm1Herc	involves: 129 * CD-1	MGI:5436259
ht2	Slc8a1^tm1Herc/Slc8a1^+	involves: 129 * CD-1	MGI:5436260

Genotype
MGI:5436259

hm1

• Allelic Composition: Slc8a1^tm1Herc/Slc8a1^tm1Herc
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:186743 )

• mice die during embryogenesis

Genotype
MGI:5436260

ht2

• Allelic Composition: Slc8a1^tm1Herc/Slc8a1⁺
• Genetic Background: involves: 129 * CD-1

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:186743 )

• at 12 weeks due to increased proliferation

abnormal pancreas physiology ( J:186743 )

• following removal of extracellular sodium, islet cells exhibit half as much of an increase in calcium uptake compared with wild-type cells

• glucose-stimulated islet cells exhibit altered internal calcium oscillations compared with wild-type cells

• at high glucose concentrations, islets exhibit lower glucose oxidation compared with wild-type cells

• under hypoxic conditions, islet cells exhibit reduced cell death compared with wild-type cells

• in transplantation experiments, islet cells are more efficient at curing diabetes compared with wild-type cell

• islet cells exhibit increased endoplasmic reticulum calcium stores compared with wild-type cells

increased pancreatic beta cell proliferation ( J:186743 )

• increased cell proliferation

abnormal exocrine pancreas physiology ( J:186743 )

• increased cell proliferation

increased insulin secretion ( J:186743 )

• stimulated islet cells exhibit higher insulin content and release compared with wild-type mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:186743 )

• at high glucose concentrations, islets exhibit lower glucose oxidation compared with wild-type cells

increased insulin secretion ( J:186743 )

• stimulated islet cells exhibit higher insulin content and release compared with wild-type mice

digestive/alimentary system

abnormal exocrine pancreas physiology ( J:186743 )

• increased cell proliferation

cellular

increased pancreatic beta cell proliferation ( J:186743 )

• increased cell proliferation