Phenotypes associated with this allele

• Allele Symbol: Ptpn2^tm2.1Ttig
• Allele Name: targeted mutation 2.1, Tony Tiganis
• Allele ID: MGI:5436249
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig	B6.Cg-Ptpn2^tm2.1Ttig	MGI:5436254

Genotype
MGI:5436254

hm1

• Allelic Composition: Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig
• Genetic Background: B6.Cg-Ptpn2^tm2.1Ttig

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Runtiness of Ptpn2^tm1Mtr/Ptpn2^tm1Mtr and Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig mice

mortality/aging

premature death ( J:186843 )

• median survival is 32 days

• some mice survive up to 50 days

growth/size/body

decreased lean body mass ( J:186843 )

• decrease in total lean mass but not in lean mass normalized to total body weight

decreased body size ( J:186843 )

• at 2 weeks of age compared to littermate controls

skeleton

skeleton phenotype ( J:186843 )

N • slight but non-significant decrease in femoral length and no overt difference in femoral width or trabecular bone volume at P14

abnormal skeleton morphology ( J:186843 )

• bones are overtly smaller at P21

decreased long bone epiphyseal plate size ( J:186843 )

• striking reduction in the growth plate width at P21

decreased bone mineral content ( J:186843 )

increased bone mineral density ( J:186843 )

• increased when normalized to body weight

adipose tissue

decreased total body fat amount ( J:186843 )

hematopoietic system

hematopoietic system phenotype ( J:186843 )

N • unlike mice homozygous for Ptpn2^tm1Mtr on a BALB/c background, splenomegaly is not detected

thymus atrophy ( J:186843 )

• at P29

decreased thymocyte number ( J:186843 )

• decrease in total cellularity at P18 with a profound decrease at P29

• decrease at P18 is less than that in mice homozygous for Ptpn2^tm1Mtr on a BALB/c background

abnormal T cell differentiation ( J:186843 )

abnormal negative T cell selection ( J:186843 )

• modest increase in the number of cell undergoing negative selection at P14-16

abnormal positive T cell selection ( J:186843 )

• increase in the number of cell undergoing positive selection at P18

decreased double-positive T cell number ( J:186843 )

• in the thymus at P18 with a profound decrease at P29

• decrease is less than that in mice homozygous for Ptpn2^tm1Mtr on a BALB/c background

abnormal bone marrow cell number ( J:186843 )

• decrease in the number of CD11b+ cells in the bone marrow

• more than an 80% decrease in CD117-Ter119+ cells in the bone marrow

decreased bone marrow cell number ( J:186843 )

decreased erythroid progenitor cell number ( J:186843 )

• more than an 80% decrease in CD117+Ter119- progenitor cells

decreased erythrocyte cell number ( J:186843 )

• more than an 80% decrease in CD117-Ter119+ cells in the bone marrow

• decrease in the number of circulating erythrocytes

decreased B cell number ( J:186843 )

• dramatic reduction in total B220+ B cells

decreased immature B cell number ( J:186843 )

• dramatic decrease in IgM^-IgD^-B220^lo progenitor B cells and IgM^hiIgD^loB220^lo immature B cells at P28

decreased mature B cell number ( J:186843 )

• dramatic reduction in IgM^intIgD^hiB220^hi mature recirculating B cells at P28

decreased B-1 B cell number ( J:186843 )

• dramatic reduction at P28

decreased follicular B cell number ( J:186843 )

• dramatic reduction at P28

decreased marginal zone B cell number ( J:186843 )

• dramatic reduction at P28

abnormal T cell subpopulation ratio ( J:186843 )

• increase in the single positive to double positive ratio at P18

decreased CD4-positive, alpha-beta T cell number ( J:186843 )

• profound decrease at P29

decreased single-positive T cell number ( J:186843 )

• profound decrease at P29

immune system

thymus atrophy ( J:186843 )

• at P29

decreased thymocyte number ( J:186843 )

• decrease in total cellularity at P18 with a profound decrease at P29

• decrease at P18 is less than that in mice homozygous for Ptpn2^tm1Mtr on a BALB/c background

abnormal T cell differentiation ( J:186843 )

abnormal negative T cell selection ( J:186843 )

• modest increase in the number of cell undergoing negative selection at P14-16

abnormal positive T cell selection ( J:186843 )

• increase in the number of cell undergoing positive selection at P18

decreased double-positive T cell number ( J:186843 )

• in the thymus at P18 with a profound decrease at P29

• decrease is less than that in mice homozygous for Ptpn2^tm1Mtr on a BALB/c background

decreased B cell number ( J:186843 )

• dramatic reduction in total B220+ B cells

decreased immature B cell number ( J:186843 )

• dramatic decrease in IgM^-IgD^-B220^lo progenitor B cells and IgM^hiIgD^loB220^lo immature B cells at P28

decreased mature B cell number ( J:186843 )

• dramatic reduction in IgM^intIgD^hiB220^hi mature recirculating B cells at P28

decreased B-1 B cell number ( J:186843 )

• dramatic reduction at P28

decreased follicular B cell number ( J:186843 )

• dramatic reduction at P28

decreased marginal zone B cell number ( J:186843 )

• dramatic reduction at P28

abnormal T cell subpopulation ratio ( J:186843 )

• increase in the single positive to double positive ratio at P18

decreased CD4-positive, alpha-beta T cell number ( J:186843 )

• profound decrease at P29

decreased single-positive T cell number ( J:186843 )

• profound decrease at P29

enlarged lymph nodes ( J:186843 )

• modest increase in weight but no change in cellularity

endocrine/exocrine glands

thymus atrophy ( J:186843 )

• at P29

decreased thymocyte number ( J:186843 )

• decrease in total cellularity at P18 with a profound decrease at P29

• decrease at P18 is less than that in mice homozygous for Ptpn2^tm1Mtr on a BALB/c background