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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1.1Wrst
targeted mutation 1.1, Wolfgang Wurst
MGI:5436308
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1.1Wrst/Pink1tm1.1Wrst involves: 129S2/SvPas * BALB/cJ * C57BL/6J MGI:5436309
cn2
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:6113544
cx3
Parltm1.1Bdes/Parltm1.1Bdes
Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129P2/OlaHsd * 129S2/SvPas MGI:6280687
cx4
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J MGI:6113417
cx5
Parltm1.1Bdes/Parltm1.1Bdes
Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi
Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6N MGI:6280690
cx6
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Tg(Prnp-SNCA*A53T)AAub/?
involves: 129S2/SvPas * C57BL/6J * FVB/N MGI:6113412
cx7
Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi
Pink1tm1.1Wrst/Pink1tm1.1Wrst
involves: 129S2/SvPas * C57BL/6N MGI:6280691


Genotype
MGI:5436309
hm1
Allelic
Composition
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129S2/SvPas * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected
• no decrease in striatal dopamine content is detected at 6 months of age
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased

behavior/neurological
N
• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls
• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age
• maximum contact is increased in the hindpaws in males at 26 months of age
• marked change in interpaw coordination
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task

cellular
• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP

taste/olfaction
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 6 DOID:0060369 OMIM:605909
J:183290




Genotype
MGI:6113544
cn2
Allelic
Composition
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Rrn3tm1.1Igt/Rrn3tm1.1Igt
Tg(Slc6a3-cre/ERT2)1Span/0
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7Gt(XE726)Byg mutation (1 available); any Park7 mutation (56 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
Rrn3tm1.1Igt mutation (2 available); any Rrn3 mutation (42 available)
Tg(Slc6a3-cre/ERT2)1Span mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants
• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants




Genotype
MGI:6280687
cx3
Allelic
Composition
Parltm1.1Bdes/Parltm1.1Bdes
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parltm1.1Bdes mutation (1 available); any Parl mutation (28 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system




Genotype
MGI:6113417
cx4
Allelic
Composition
Park7Gt(XE726)Byg/Park7Gt(XE726)Byg
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7Gt(XE726)Byg mutation (1 available); any Park7 mutation (56 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• mice do not exhibit impaired nucleolar activity in dopaminergic neurons with unaltered rDNA transcription




Genotype
MGI:6280690
cx5
Allelic
Composition
Parltm1.1Bdes/Parltm1.1Bdes
Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parltm1.1Bdes mutation (1 available); any Parl mutation (28 available)
Pgam5tm1d(EUCOMM)Wtsi mutation (0 available); any Pgam5 mutation (26 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system




Genotype
MGI:6113412
cx6
Allelic
Composition
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Tg(Prnp-SNCA*A53T)AAub/?
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
Tg(Prnp-SNCA*A53T)AAub mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice show a reduced life span

nervous system
• nucleolar integrity is disrupted in dopaminergic neurons, with the percentage of TH+ dopaminergic neurons containing one nucleolus being lower in the substantia nigra and ventral tagmental area and an increase in the percentage of dopaminergic neurons showing no nucleolar staining
• number of dopaminergic neurons containing 2 or 3 nucleoli is higher

cellular
• nucleolar integrity is disrupted in dopaminergic neurons, with the percentage of TH+ dopaminergic neurons containing one nucleolus being lower in the substantia nigra and ventral tagmental area and an increase in the percentage of dopaminergic neurons showing no nucleolar staining
• number of dopaminergic neurons containing 2 or 3 nucleoli is higher
• nucleolar activity is altered with downregulation in a subset of dopaminergic neurons while upregulation of rRNA synthesis is seen in another group of dopaminergic neurons suggesting initial compensatory mechanisms

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:242309




Genotype
MGI:6280691
cx7
Allelic
Composition
Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi
Pink1tm1.1Wrst/Pink1tm1.1Wrst
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgam5tm1d(EUCOMM)Wtsi mutation (0 available); any Pgam5 mutation (26 available)
Pink1tm1.1Wrst mutation (0 available); any Pink1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit a normal lifespan





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory