nervous system
N |
• no signs of dopaminergic neurodegeneration or other obvious morphological changes in the substantia nigra pars compacta or the striatum are detected
• no decrease in striatal dopamine content is detected at 6 months of age
|
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
|
• serotonergic innervation in the glomerular layer of the olfactory bulb is significantly decreased
|
behavior/neurological
N |
• locomotor activity, anxiety related behavior, depression related behavior, and object recognition are similar to controls
|
• decrease in the base of support for, print length of, and stand duration of the hindpaws in males at 26 months of age
• maximum contact is increased in the hindpaws in males at 26 months of age
• marked change in interpaw coordination
|
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
|
• young male mice, but not female mice, do not spend more time exploring a novel than a familiar conspecifc in a social discrimination task
|
cellular
• decrease in the percentage of fragmented mitochondria and increase in the percentage of intermediate mitochondria in neurons compared to wild-type controls following transduction with a lentiviral vector expressing mitochondrially targeted eYFP
|
taste/olfaction
• aged (27 months) males display impairments in fine olfactory discrimination abilities and olfactory sensitivity
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Parkinson's disease 6 | DOID:0060369 |
OMIM:605909 |
J:183290 |