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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adartm2Knk
targeted mutation 2, Kazuko Nishikura
MGI:5436438
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Adartm2Knk/Adar+ chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5436439


Genotype
MGI:5436439
ht1
Allelic
Composition		 Adartm2Knk/Adar+
Genetic
Background		 chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Knk mutation (0 available); any Adar mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:65981 )
• no live embryos after E14.5
• some 90% chimeric embryos survive to E12.5-E13.5
• embryos normal up to E11.5

hematopoietic system
abnormal embryonic erythropoiesis ( J:65981 )
• more than 90% of circulating erythrocytes remain nucleated
• some circulating erythrocytes undergo mitosis

liver/biliary system
abnormal liver development ( J:65981 )
• "lacy" appearance of livers at E12.5-E13.5
• hematopoietic islands are present

embryo
abnormal embryonic erythropoiesis ( J:65981 )
• more than 90% of circulating erythrocytes remain nucleated
• some circulating erythrocytes undergo mitosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory