Phenotypes associated with this allele

• Allele Symbol: Acot13^tm1Deco
• Allele Name: targeted mutation 1, David E Cohen
• Allele ID: MGI:5437122
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acot13^tm1Deco/Acot13^tm1Deco	involves: 129 * C57BL/6	MGI:5437125
hm2	Acot13^tm1Deco/Acot13^tm1Deco	Not Specified	MGI:6105929

Genotype
MGI:5437125

hm1

• Allelic Composition: Acot13^tm1Deco/Acot13^tm1Deco
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating ketone body level ( J:183258 )

• mice fed a high fat diet fail to exhibit an increase in circulating ketone body levels (beta-hydroxybutyrate) unlike wild-type mice

decreased oxygen consumption ( J:183258 )

• in mice fed a high-fat diet

decreased respiratory quotient ( J:183258 )

• in mice fed a high-fat diet

abnormal glucose homeostasis ( J:183258 )

• mice fed a high fat diet exhibit increased glucose clearance compared with wild-type mice

abnormal gluconeogenesis ( J:183258 )

• mice fed a high fat diet exhibit reduced hepatic glucose production compared with wild-type mice

improved glucose tolerance ( J:183258 )

• in mice fed a high fat diet

abnormal lipid level ( J:183258 )

• mice fed standard chow exhibit reduced intestinal lipid absorption compared with wild-type mice

• mice fed standard chow exhibit increased feces lipid composition compared with wild-type mice

• however, mice fed a high-fat diet exhibit normal lipid absorption

abnormal feces lipid level ( J:183258 )

• mice fed standard chow exhibit increased feces lipid composition, including triglycerides, compared with wild-type mice

decreased circulating free fatty acids level ( J:183258 )

• mice fed a high fat diet fail to exhibit an increase in circulating free fatty acids unlike wild-type mice

decreased liver cholesterol level ( J:183258 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:183258 )

• in mice fed a high fat diet

decreased basal metabolism ( J:183258 )

• mice fed a high-fat diet exhibit decreased heat production compared with wild-type mice

abnormal enzyme/coenzyme activity ( J:183258 )

• mice exhibit reduced mitochondrial fatty acyl-CoA thioesterase activity in the liver compared with wild-type mice

adipose tissue

decreased white adipose tissue amount ( J:183258 )

• in mice fed standard chow or a high fat diet

decreased epididymal fat pad weight ( J:183258 )

• in mice fed standard chow or a high fat diet

growth/size/body

increased lean body mass ( J:183258 )

• in mice fed standard chow or a high fat diet

decreased body weight ( J:183258 )

• modest in mice fed standard chow or a high fat diet

behavior/neurological

abnormal eating behavior ( J:183258 )

• in mice fed standard chow or a high fat diet

decreased locomotor activity ( J:183258 )

• during the light phase in mice fed standard chow

digestive/alimentary system

abnormal feces lipid level ( J:183258 )

• mice fed standard chow exhibit increased feces lipid composition, including triglycerides, compared with wild-type mice

liver/biliary system

decreased liver cholesterol level ( J:183258 )

• in mice fed a high fat diet

decreased liver triglyceride level ( J:183258 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:183258 )

• in mice fed a high-fat diet

Genotype
MGI:6105929

hm2

• Allelic Composition: Acot13^tm1Deco/Acot13^tm1Deco
• Genetic Background: Not Specified

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:204997 )

• increased core body temperature early during the dark phase, but not in the light phase, when housed at 30C and more pronounced at 22C

• increased core body temperature at the dark phase in mice housed at 22C when food is removed at the beginning of the dark phase and when mice were subsequently refed during the light phase

increased core body temperature ( J:204997 )

• early during the dark phase, but not in the light phase, when housed at 30C and more pronounced at 22C

• at the dark phase in mice housed at 22C when food is removed at the beginning of the dark phase and when mice were subsequently refed during the light phase

• however, genotype and diurnal variations are lost

abnormal circadian temperature homeostasis ( J:204997 )

• increased core body temperature early during the dark phase, but not in the light phase, when housed at 30C and more pronounced at 22C

• however, genotype and diurnal variations are lostn at 4C

increased energy expenditure ( J:204997 )

• over a 24 hr period, in the light phase and in the dark phase when housed at 22C or 4C

• in the dark phase only when mice are housed at 30C

increased oxygen consumption ( J:204997 )

• in the dark phase in mice housed at 30C or 22C

• in the light and dark phase at 4C

• in mice following food withdrawal and refeeding

• however, food withdrawal eliminates differences

increased respiratory quotient ( J:204997 )

• slightly at 4C, but not at 30C or 22C

• in mice following food withdrawal and refeeding

• however, food withdrawal eliminates differences

growth/size/body

increased lean body mass ( J:204997 )

• at 22C

increased body weight ( J:204997 )

• initially but not after 24 h at 4C

behavior/neurological

decreased food intake ( J:204997 )

• during the light phase when mice were housed at 30C

increased food intake ( J:204997 )

• during the dark phase when mice were housed at 30C

• slight during the light phase and more so during the dark phase when mice are housed at 22C

• during the light and dark phase of cold-exposed mice

hyperactivity ( J:204997 )

• over 24 h and during the dark phase at both 30C and 22C

• however, activity levels are not altered by food withdrawal

adipose tissue

decreased brown fat cell lipid droplet size ( J:204997 )