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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox7tm1Dsco
targeted mutation 1, Daryl A Scott
MGI:5437220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sox7tm1Dsco/Sox7tm1.1Dsco
Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * C57BL/6 * SJL MGI:7543476
cn2
Sox7tm1Dsco/Sox7tm1Dsco
Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * C57BL/6 * SJL MGI:7543477


Genotype
MGI:7543476
cn1
Allelic
Composition
Sox7tm1Dsco/Sox7tm1.1Dsco
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1.1Dsco mutation (0 available); any Sox7 mutation (21 available)
Sox7tm1Dsco mutation (0 available); any Sox7 mutation (21 available)
Tg(Tek-cre)1Ywa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most embryos die prior to E15.5; two rare survivors are found at E15.5

cardiovascular system
• one of 2 rare embryos that survived to E15.5 show a ventricular septal defect (VSD), not observed in control embryos




Genotype
MGI:7543477
cn2
Allelic
Composition
Sox7tm1Dsco/Sox7tm1Dsco
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1Dsco mutation (0 available); any Sox7 mutation (21 available)
Tg(Tek-cre)1Ywa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most embryos died prior to E15.5; one rare survivor was found at E15.5

cardiovascular system
• at E10.5, atrioventricular (AV) endocardial cushions were hypocellular with a severe reduction in mesenchymal cell density relative to control embryos
• single embryo that survived to E15.5 showed a ventricular septal defect (VSD)





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory