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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock8tm1Ysfk
targeted mutation 1, Yoshinori Fukui
MGI:5437274
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock8tm1Ysfk/Dock8tm1Ysfk B6.Cg-Dock8tm1Ysfk MGI:5437279
cx2
 		Dock8tm1Ysfk/Dock8tm1Ysfk
Osmrtm1Mtan/Osmrtm1Mtan
Tg(TcrAND)53Hed/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:7643972
cx3
 		Dock8tm1Ysfk/Dock8tm1Ysfk
Tg(TcrAND)53Hed/0 		involves: C57BL/6 * SJL MGI:7643971
cx4
 		Dock8tm1Ysfk/Dock8tm1Ysfk
Il31tm1.1Ysfk/Il31tm1.1Ysfk
Tg(TcrAND)53Hed/0 		involves: C57BL/6 * SJL MGI:7643974
cx5
 		Dock8tm1Ysfk/Dock8tm1Ysfk
Tac2em1Ysfk/Tac2em1Ysfk
Tg(TcrAND)53Hed/0 		involves: C57BL/6 * SJL MGI:7643975
cx6
 		Dock8tm1Ysfk/Dock8tm1Ysfk
Tac2em2Ysfk/Tac2em2Ysfk
Tg(TcrAND)53Hed/0 		involves: C57BL/6 * SJL MGI:7643976


Genotype
MGI:5437279
hm1
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic
Background		 B6.Cg-Dock8tm1Ysfk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:185165 )
• after ovalbumin stimulation of CD4+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:185165 )
• in the spleen and peripheral lymph node
decreased CD8-positive, alpha-beta T cell number ( J:185165 )
• in the spleen and peripheral lymph node
decreased IgG level ( J:185165 )
• after ovalbumin stimulation
decreased follicular dendritic cell number ( J:185165 )
• in draining lymph nodes during immune response
abnormal dendritic cell physiology ( J:185165 )
• dendritic cell (DC) trafficking during immune response is impaired compared to in wild-type cells
• DC exhibit impaired migration in 3D environments compared with wild-type cells
• DC exhibit impaired transmigration through subcapsular sinus compared with wild-type cells
• however, migration in a 2D environments is normal

hematopoietic system
decreased T cell proliferation ( J:185165 )
• after ovalbumin stimulation of CD4+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:185165 )
• in the spleen and peripheral lymph node
decreased CD8-positive, alpha-beta T cell number ( J:185165 )
• in the spleen and peripheral lymph node
decreased IgG level ( J:185165 )
• after ovalbumin stimulation

cellular
decreased T cell proliferation ( J:185165 )
• after ovalbumin stimulation of CD4+ T cells




Genotype
MGI:7643972
cx2
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Osmrtm1Mtan/Osmrtm1Mtan
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Osmrtm1Mtan mutation (1 available); any Osmr mutation (56 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:305132 )
N
• mice show improved skin inflammation and scratching behavior and do not develop atopic dermatitis-like skin disease that is seen in Dock8tm1Ysfk/Dock8tm1Ysfk Tg(TcrAND)53Hed/0 mice




Genotype
MGI:7643971
cx3
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:305132 )
• mice develop an atopic dermatitis-like skin disease, with increased skin inflammation and scratching behavior

integument
dermatitis ( J:305132 )
• mice develop an atopic dermatitis-like skin disease, with increased skin inflammation and scratching behavior

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165
OMIM:PS603165
 J:305132




Genotype
MGI:7643974
cx4
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Il31tm1.1Ysfk/Il31tm1.1Ysfk
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Il31tm1.1Ysfk mutation (0 available); any Il31 mutation (13 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:305132 )
N
• mice show improved skin inflammation and scratching behavior and do not develop atopic dermatitis-like skin disease that is seen in Dock8tm1Ysfk/Dock8tm1Ysfk Tg(TcrAND)53Hed/0 mice




Genotype
MGI:7643975
cx5
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Tac2em1Ysfk/Tac2em1Ysfk
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Tac2em1Ysfk mutation (0 available); any Tac2 mutation (18 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:305132 )
N
• mice show improved skin inflammation and scratching behavior compared to Dock8tm1Ysfk/Dock8tm1Ysfk Tg(TcrAND)53Hed/0 mice, without affecting serum IL-31 levels




Genotype
MGI:7643976
cx6
Allelic
Composition		 Dock8tm1Ysfk/Dock8tm1Ysfk
Tac2em2Ysfk/Tac2em2Ysfk
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8tm1Ysfk mutation (0 available); any Dock8 mutation (103 available)
Tac2em2Ysfk mutation (0 available); any Tac2 mutation (18 available)
Tg(TcrAND)53Hed mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:305132 )
N
• mice show improved skin inflammation and scratching behavior compared to Dock8tm1Ysfk/Dock8tm1Ysfk Tg(TcrAND)53Hed/0 mice, without affecting serum IL-31 levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory