Phenotypes associated with this allele

• Allele Symbol: Antxr2^tm1.1Jkit
• Allele Name: targeted mutation 1.1, Jan K Kitajewski
• Allele ID: MGI:5437300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit	involves: 129 * C57BL/6	MGI:5437301

Genotype
MGI:5437301

hm1

• Allelic Composition: Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reproductive tract abnormalities in aged nulliparous Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit mice

mortality/aging

pregnancy-related premature death ( J:187210 )

♀ • young females (6 weeks of age) fail to deliver pups and die about 1 week after their expected due date

reproductive system

reproductive system phenotype ( J:187210 )

♀N • increased collagen deposition is not detected in the ovaries

abnormal internal female genitalia morphology ( J:187210 )

♀ • at 3-15 months of age, the reproductive tract is shorter and thicker compared to controls

♀ • accumulation of extracellular matrix in the reproductive tract

abnormal uterus morphology ( J:187210 )

♀ • progressive collagen fibrosis in sexually mature females resulting in a thickened, collagen dense, acellular stroma and the disappearance of normal uterine morphology

♀ • blood and lymphatic vessels are dilated

abnormal myometrium morphology ( J:187210 )

♀ • at 6.5 weeks of age loosening of the circular and the outer longitudinal layers of myometrial cells is seen resulting in increased intercellular space between bundles of muscle cells

♀ • loosening progresses with age and by 3 months of age the circular layer consists of a poorly defined layer of scattered cells and the space between the circular and longitudinal layers is distended

♀ • the circular and the outer longitudinal layers of myometrial cells are disorganized in aged nulliparous mice

♀ • the longitudinal layer is almost completely ablated

abnormal uterine cervix morphology ( J:187210 )

♀ • increased collagen content at 15 months of age

♀ • blood and lymphatic vessels are dilated

increased miscarriage rate ( J:187210 )

♀ • at 2 to 6 months of age, about half of pregnant females miscarry litters

parturition failure ( J:187210 )

♀ • young females fail to deliver pups regardless of pup genotype

abnormal uterus physiology ( J:187210 )

♀ • increase in cell death in luminal and glandular epithelial cells in uterine tissue aged 6 months and beyond

♀ • far greater infiltration of inflammatory cells compared to wild-type controls

female infertility ( J:187210 )

♀ • females at 7 months of age or above are unable to get pregnant

cardiovascular system

dilated vasculature ( J:187210 )

♀ • in the uterus

cellular

increased apoptosis ( J:187210 )

♀ • increase in cell death in luminal and glandular epithelial cells in uterine tissue aged 6 months and beyond

immune system

lymphangiectasis ( J:187210 )

♀ • in the uterus