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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat5btm2.1Wjl
targeted mutation 2.1, Warren J Leonard
MGI:5437318
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat5btm2.1Wjl/Stat5btm2.1Wjl involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5437326
cx2
 		Stat5atm1.1Wjl/Stat5atm1.1Wjl
Stat5btm2.1Wjl/Stat5btm2.1Wjl 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5437327


Genotype
MGI:5437326
hm1
Allelic
Composition		 Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5btm2.1Wjl mutation (0 available); any Stat5b mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:187325 )
• mice are viable, are normal in weight and have normal peripheral leukocyte numbers




Genotype
MGI:5437327
cx2
Allelic
Composition		 Stat5atm1.1Wjl/Stat5atm1.1Wjl
Stat5btm2.1Wjl/Stat5btm2.1Wjl
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1.1Wjl mutation (0 available); any Stat5a mutation (48 available)
Stat5btm2.1Wjl mutation (0 available); any Stat5b mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:187325 )
• in CD8+ T cells following IL2 withdrawal
decreased T cell proliferation ( J:187325 )
• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal
abnormal leukocyte morphology ( J:187325 )
• slight increase in splenic B to T cell ratio compared to in control mice
• however, total numbers are normal
abnormal T cell subpopulation ratio ( J:187325 )
• the ratio of CD4 to CD8 is modestly increased compared to in control mice
abnormal regulatory T cell physiology ( J:187325 )
• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells

cellular
increased T cell apoptosis ( J:187325 )
• in CD8+ T cells following IL2 withdrawal
decreased T cell proliferation ( J:187325 )
• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal

hematopoietic system
increased T cell apoptosis ( J:187325 )
• in CD8+ T cells following IL2 withdrawal
decreased T cell proliferation ( J:187325 )
• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal
decreased erythrocyte cell number ( J:187325 )
• in neonates but not adults
decreased hematocrit ( J:187325 )
• in neonates but not adults
decreased hemoglobin content ( J:187325 )
• in neonates but not adults
abnormal leukocyte morphology ( J:187325 )
• slight increase in splenic B to T cell ratio compared to in control mice
• however, total numbers are normal
abnormal T cell subpopulation ratio ( J:187325 )
• the ratio of CD4 to CD8 is modestly increased compared to in control mice
abnormal regulatory T cell physiology ( J:187325 )
• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory