normal phenotype
• mice are viable, are normal in weight and have normal peripheral leukocyte numbers
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Allele Symbol Allele Name Allele ID |
Stat5btm2.1Wjl targeted mutation 2.1, Warren J Leonard MGI:5437318 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are viable, are normal in weight and have normal peripheral leukocyte numbers
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• in CD8+ T cells following IL2 withdrawal
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• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal
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• slight increase in splenic B to T cell ratio compared to in control mice
• however, total numbers are normal
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• the ratio of CD4 to CD8 is modestly increased compared to in control mice
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• slight
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• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells
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• in CD8+ T cells following IL2 withdrawal
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• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal
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• in CD8+ T cells following IL2 withdrawal
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• induced by cytokines or LCMV
• however, proliferation induced by anti-CD3 and anti-CD28 is almost normal
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• in neonates but not adults
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• in neonates but not adults
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• in neonates but not adults
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• slight increase in splenic B to T cell ratio compared to in control mice
• however, total numbers are normal
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• the ratio of CD4 to CD8 is modestly increased compared to in control mice
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• slight
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• T regulatory cells transferred into Rag2 null mice exhibit increased colitis compared with mice receiving wild-type cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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