Phenotypes associated with this allele

• Allele Symbol: Pabpc1l^tm1.1Esel
• Allele Name: targeted mutation 1.1, Emre Seli
• Allele ID: MGI:5437740
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pabpc1l^tm1.1Esel/Pabpc1l^tm1.1Esel	involves: 129S1/SvImJ * C57BL/6J	MGI:5437751

Genotype
MGI:5437751

hm1

• Allelic Composition: Pabpc1l^tm1.1Esel/Pabpc1l^tm1.1Esel
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oogenesis ( J:187525 )

♀ • increased oocyte retention

abnormal oocyte morphology ( J:187525 )

♀ • longated shapes, pronounced cytoplasmic granularity and abnormal polar-body-like structure

decreased oocyte number ( J:187525 )

♀ • fewer total oocytes and no mature MII oocytes are detected

abnormal spindle assembly in female meiosis ( J:187525 )

♀ • abnormal spindle formation and chromosome alignment at the metaphase plate

abnormal ovarian follicle morphology ( J:187525 )

♀ • some follicles have 2 or 3 layers of granulosa cells indicating the beginnings of premature antrum formation

increased secondary ovarian follicle number ( J:187525 )

♀ • 3-fold increase in number of secondary follicles

decreased cumulus expansion ( J:187525 )

♀

polyovular ovarian follicle ( J:187525 )

♀ • some follicles house 2 oocytes

decreased ovulation rate ( J:187525 )

♀ • impaired ovulation

female infertility ( J:187525 )

♀ • despite normal estrous cycle and mating behavior

impaired fertilization ( J:187525 )

♀ • after super-ovulation of female mice and breeding with wild-type males, no two-cell embryos are collected 42 h later

cellular

abnormal cell physiology ( J:187525 )

♀ • maternal genes fail to be polyadenylated

abnormal oogenesis ( J:187525 )

♀ • increased oocyte retention

abnormal oocyte morphology ( J:187525 )

♀ • longated shapes, pronounced cytoplasmic granularity and abnormal polar-body-like structure

decreased oocyte number ( J:187525 )

♀ • fewer total oocytes and no mature MII oocytes are detected

abnormal spindle assembly in female meiosis ( J:187525 )

♀ • abnormal spindle formation and chromosome alignment at the metaphase plate

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:187525 )

♀ • some follicles have 2 or 3 layers of granulosa cells indicating the beginnings of premature antrum formation

increased secondary ovarian follicle number ( J:187525 )

♀ • 3-fold increase in number of secondary follicles

decreased cumulus expansion ( J:187525 )

♀

polyovular ovarian follicle ( J:187525 )

♀ • some follicles house 2 oocytes