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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Timd4tm1Osa
targeted mutation 1, Shigekazu Nagata
MGI:5438219
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Timd4tm1Osa/Timd4tm1Osa involves: C57BL/6 MGI:5438220
cx2
Mfge8tm1Osa/Mfge8tm1Osa
Timd4tm1Osa/Timd4tm1Osa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5438221


Genotype
MGI:5438220
hm1
Allelic
Composition
Timd4tm1Osa/Timd4tm1Osa
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timd4tm1Osa mutation (1 available); any Timd4 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• Background Sensitivity: mice exhibit normal autoantibody levels when on a C57BL/6 background
• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells
• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis

hematopoietic system
• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells
• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis

cellular
• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells
• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis




Genotype
MGI:5438221
cx2
Allelic
Composition
Mfge8tm1Osa/Mfge8tm1Osa
Timd4tm1Osa/Timd4tm1Osa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
Timd4tm1Osa mutation (1 available); any Timd4 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• by 30 weeks of age in female mice
• at 7 weeks after anti-Tnfa antibody treatment in female mice
• however, male mice exhibit normal autoantibody levels
• by 30 weeks of age in female mice
• however, male mice exhibit normal autoantibody levels

hematopoietic system

cellular





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory