All Phenotypes Timd4<tm1Osa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Timd4^tm1Osa
targeted mutation 1, Shigekazu Nagata
MGI:5438219

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timd4^tm1Osa/Timd4^tm1Osa	involves: C57BL/6	MGI:5438220
cx2	Mfge8^tm1Osa/Mfge8^tm1Osa Timd4^tm1Osa/Timd4^tm1Osa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5438221

Allelic Composition	Timd4^tm1Osa/Timd4^tm1Osa
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timd4^tm1Osa mutation (1 available); any Timd4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:187181 )

N	• Background Sensitivity: mice exhibit normal autoantibody levels when on a C57BL/6 background

impaired macrophage phagocytosis ( J:187181 )

• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells

• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis

hematopoietic system

impaired macrophage phagocytosis ( J:187181 )

• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells

• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis

cellular

impaired macrophage phagocytosis ( J:187181 )

• peritoneal macrophages exhibit impaired ability to engulf apoptotic cells compared with wild-type cells

• however, thyoglycollate-elecited macrophages exhibit normal phagocytosis

Allelic Composition	Mfge8^tm1Osa/Mfge8^tm1Osa Timd4^tm1Osa/Timd4^tm1Osa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8^tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
Timd4^tm1Osa mutation (1 available); any Timd4 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage phagocytosis ( J:187181 )

increased anti-nuclear antigen antibody level ( J:187181 )

• by 30 weeks of age in female mice

• at 7 weeks after anti-Tnfa antibody treatment in female mice

• however, male mice exhibit normal autoantibody levels

increased anti-double stranded DNA antibody level ( J:187181 )

• by 30 weeks of age in female mice

• however, male mice exhibit normal autoantibody levels

hematopoietic system

impaired macrophage phagocytosis ( J:187181 )

cellular

impaired macrophage phagocytosis ( J:187181 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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