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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il34tm1b(EUCOMM)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5438224
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il34tm1b(EUCOMM)Wtsi/Il34tm1b(EUCOMM)Wtsi involves: BALB/cJ * C57BL/6N MGI:5438232


Genotype
MGI:5438232
hm1
Allelic
Composition
Il34tm1b(EUCOMM)Wtsi/Il34tm1b(EUCOMM)Wtsi
Genetic
Background
involves: BALB/cJ * C57BL/6N
Cell Lines EPD0146_4_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il34tm1b(EUCOMM)Wtsi mutation (0 available); any Il34 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice treated with an attenuated West Nile virus strain exhibit increased death compared with control mice
• however, mice exposed to un-attenuated West Nile virus exhibit normal mortality

immune system
N
• mice exhibit normal myeloid cell development in the liver
• lung dendritic cell numbers are decreased compared to in wild-type mice
• however, mice exhibit normal epidermal and splenic dendritic cell migration and numbers
• in the epidermis
• however, mice exposed to ultraviolet light exhibit regeneration of Langerhans cells
• in the skin of neonates
• impaired microglia cell numbers in untreated mice and mice exposed to attenuated West Nile virus
• neonates exhibit reduced microglial cell numbers compared with control mice
• in the inguinal lymph nodes of mice exposed to C. albicans
• DNFB-mediated with reduced ear swelling, T cell priming, Langerhan cell migration, IFN-gamma production
• mice exposed to C. albicans exhibit reduced foot pad swelling and fewer cells draining into the lymph nodes compared with control mice
• in lymph node cells from mice treated with DNFB and stimulated with anti-CD3
• mice exposed to C. albicans exhibit reduced foot pad swelling and fewer cells draining into the lymph nodes compared with control mice
• mice treated with an attenuated West Nile virus strain exhibit increased neuronal apoptosis and death with decreased microglia cells compared with control mice
• however, mice exposed to un-attenuated West Nile virus exhibit normal mortality
• mice treated with an attenuated West Nile virus strain exhibit increased death compared with control mice
• however, mice exposed to un-attenuated West Nile virus exhibit normal mortality

nervous system
• in mice treated with an attenuated West Nile virus strain
• impaired microglia cell numbers in untreated mice and mice exposed to attenuated West Nile virus
• neonates exhibit reduced microglial cell numbers compared with control mice

cellular
• in mice treated with an attenuated West Nile virus strain

hematopoietic system
• lung dendritic cell numbers are decreased compared to in wild-type mice
• however, mice exhibit normal epidermal and splenic dendritic cell migration and numbers
• in the epidermis
• however, mice exposed to ultraviolet light exhibit regeneration of Langerhans cells
• in the skin of neonates
• impaired microglia cell numbers in untreated mice and mice exposed to attenuated West Nile virus
• neonates exhibit reduced microglial cell numbers compared with control mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory