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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cul4btm1Swl
targeted mutation 1, Shu-Wha Lin
MGI:5438236
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl MGI:5438241


Genotype
MGI:5438241
cn1
Allelic
Composition		 Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4btm1Swl mutation (0 available); any Cul4b mutation (37 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:187403 )
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
abnormal dendritic spine morphology ( J:187403 )
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
decreased neuron number ( J:187403 )
• fewer PV+ hippocampal neurons
• however, mice exhibit normal numbers of SS+ and GAD67+ neurons

behavior/neurological
abnormal spatial learning ( J:187403 )
• impaired in a Morris water maze
impaired spatial working memory ( J:187403 )
• impaired in a Morris water maze

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:187403




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory