Analysis Tools
hematopoietic system
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• bone marrow cells exhibit normal reactive oxygen species levels and hematopoietic stem cell repopulation capacity
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• with age
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• older mice exhibit a reduction in mature cells and an increase in immature cells compared with control mice
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• granulocyte-macrophage (GM), granulocyte-erythrocyte-macrophage-megakaryocyte (GEMM), and macrophage (M) colonies from splenocytes
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• in older mice
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• granulocyte-macrophage (GM), granulocyte-erythrocyte-macrophage-megakaryocyte (GEMM), and macrophage (M) colonies from splenocytes
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• in older mice
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• in older mice
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• in the spleen of older mice
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• in the spleen of older mice
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• in the bone marrow of older mice
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• in the spleen of older mice
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• a 1.8-fold increase in LSK cells in young mice
• a 5.4-fold increase in LSK cells in young mice
• age-dependent increase in lineage-restricted progenitors
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• splenic architecture becomes increasingly disorganized with age-dependent expansion of the spaces between lymphoid follicles
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• mild in young mice
• overt in older mice
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• bone marrow cells continue to grow in culture after control cells stop proliferating
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homeostasis/metabolism
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• 10-fold increase in R-2-hydroxyglutarate
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immune system
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• in the spleen of older mice
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• in the spleen of older mice
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• in the bone marrow of older mice
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• in the spleen of older mice
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• splenic architecture becomes increasingly disorganized with age-dependent expansion of the spaces between lymphoid follicles
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• mild in young mice
• overt in older mice
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growth/size/body
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• mild in young mice
• overt in older mice
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