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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ago4tm1.1Peco
targeted mutation 1.1, Paula E Cohen
MGI:5438526
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ago4tm1.1Peco/Ago4tm1.1Peco B6.129P2(FVB)-Ago4tm1.1Peco MGI:5438527


Genotype
MGI:5438527
hm1
Allelic
Composition		 Ago4tm1.1Peco/Ago4tm1.1Peco
Genetic
Background		 B6.129P2(FVB)-Ago4tm1.1Peco
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago4tm1.1Peco mutation (1 available); any Ago4 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:187588 )
N
• males and females are fertile although complete reproductive histories are not reported
abnormal male germ cell morphology ( J:187588 )
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
oligozoospermia ( J:187588 )
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
abnormal male meiosis ( J:187588 )
• disruption of sex body formation and mislocalization of sex body components including the synaptonemal complex
• premature entry into meiosis
• fail to correctly silence X and Y chromosomes during meiosis
abnormal synaptonemal complex ( J:187588 )
• localization of SYCP1 indicates a defect in synaptonemal complex formation and or integrity within the sex body
increased male germ cell apoptosis ( J:187588 )
• increased apoptosis within the prophase I layers of the seminiferous epithelium
decreased testis weight ( J:187588 )
• decreased by 13% compared to controls

cellular
abnormal male germ cell morphology ( J:187588 )
• decrease in the total number of leptotene cells and concomitant increase in the number of zygonema/pachynema intermediate cells
oligozoospermia ( J:187588 )
• decreased by 22% compared to controls
• sperm samples collected from cauda epididymides
abnormal male meiosis ( J:187588 )
• disruption of sex body formation and mislocalization of sex body components including the synaptonemal complex
• premature entry into meiosis
• fail to correctly silence X and Y chromosomes during meiosis
abnormal synaptonemal complex ( J:187588 )
• localization of SYCP1 indicates a defect in synaptonemal complex formation and or integrity within the sex body
increased male germ cell apoptosis ( J:187588 )
• increased apoptosis within the prophase I layers of the seminiferous epithelium

endocrine/exocrine glands
decreased testis weight ( J:187588 )
• decreased by 13% compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory