Phenotypes associated with this allele

• Allele Symbol: Nrarp^tm1Grid
• Allele Name: targeted mutation 1, Tom Gridley
• Allele ID: MGI:5438570
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrarp^tm1Grid/Nrarp^tm1Grid	either: (involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ ) or (involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * C57BL/6J)	MGI:5438574
hm2	Nrarp^tm1Grid/Nrarp^tm1Grid	involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ	MGI:5438573
hm3	Nrarp^tm1Grid/Nrarp^tm1Grid	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	MGI:5438572

Genotype
MGI:5438574

hm1

• Allelic Composition: Nrarp^tm1Grid/Nrarp^tm1Grid
• Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ ) or (involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

craniofacial phenotype ( J:187871 )

N • mice do not exhibit obvious craniofacial defects

growth/size/body

postnatal growth retardation ( J:187871 )

• modest

Genotype
MGI:5438573

hm2

• Allelic Composition: Nrarp^tm1Grid/Nrarp^tm1Grid
• Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

skeleton

rib fusion ( J:187871 )

• Background Sensitivity: more severe than on a mixed 129 and C57BL/6J background

vertebral fusion ( J:187871 )

• in the thoracic, lumbar, sacral and caudal regions but not cervical

• fusion of adjacent vertebral bodies and pedicles

• Background Sensitivity: mice on a pure 129 background exhibit increased penetrance and expressivity of vertebral abnormalities compared to on a mixed 129 and C57BL/6J background

caudal vertebral fusion ( J:187871 )

thoracic vertebral fusion ( J:187871 )

lumbar vertebral fusion ( J:187871 )

sacral vertebral fusion ( J:187871 )

nervous system

fused dorsal root ganglion ( J:187871 )

abnormal spinal nerve morphology ( J:187871 )

• defects in projection of the spinal nerves

embryo

abnormal dorsal-ventral polarity of the somites ( J:187871 )

• mice exhibit defects in anterior-posterior somite patterning with expansion of the posterior compartment compared with wild-type mice

• however, progression of the segmentation clock occurs

hematopoietic system

hematopoietic system phenotype ( J:187871 )

N • mice do not exhibit obvious hematopoietic defects

limbs/digits/tail

caudal vertebral fusion ( J:187871 )

Genotype
MGI:5438572

hm3

• Allelic Composition: Nrarp^tm1Grid/Nrarp^tm1Grid
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

skeleton

rib fusion ( J:187871 )

• at low penetrance

• Background Sensitivity: less severe than on a pure 129 background

vertebral fusion ( J:187871 )

• in the thoracic, lumbar, sacral and caudal regions but not cervical

• fusion of adjacent vertebral bodies and pedicles

• Background Sensitivity: mice on a mixed 129 and C57BL/6J background exhibit less penetrance and expressivity of vertebral abnormalities compared to on a pure 129 background

• Background Sensitivity: additional backcrossing to C67BL/6J rescues all but the defects in the ninth and tenth thoracic vertebra

caudal vertebral fusion ( J:187871 )

thoracic vertebral fusion ( J:187871 )

lumbar vertebral fusion ( J:187871 )

sacral vertebral fusion ( J:187871 )

fusion of vertebral bodies ( J:187871 )

limbs/digits/tail

caudal vertebral fusion ( J:187871 )