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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh
targeted mutation 6, Bernhard G Herrmann
MGI:5438577
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6 MGI:5438589


Genotype
MGI:5438589
ht1
Allelic
Composition		 Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm6(tetO-dTomato,-Ctnnb1*)Bgh mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:187862 )
• crypt-derived organoids rapidly form clonogenic spheroids in vitro when treated with doxycycline, in which self-renewal capacity correlates with expression of the inserted sequence
• doxycycline-induced spheroid cultures deprived of doxycycline and treated with R-Spondin retain the ability to form major lineages of untransformed intestinal epithelium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory