Phenotypes associated with this allele

• Allele Symbol: Crim1^tm1.1Dpen
• Allele Name: targeted mutation 1.1, David J Pennisi
• Allele ID: MGI:5438615
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crim1^tm1.1Dpen/Crim1^tm1.1Dpen	B6.129P2(129S7)-Crim1^tm1.1Dpen	MGI:5438633
hm2	Crim1^tm1.1Dpen/Crim1^tm1.1Dpen	either: (B6.129P2(129S7)-Crim1^tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)	MGI:5438635
hm3	Crim1^tm1.1Dpen/Crim1^tm1.1Dpen	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1	MGI:5438634

Genotype
MGI:5438633

hm1

• Allelic Composition: Crim1^tm1.1Dpen/Crim1^tm1.1Dpen
• Genetic Background: B6.129P2(129S7)-Crim1^tm1.1Dpen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:187855 )

Genotype
MGI:5438635

hm2

• Allelic Composition: Crim1^tm1.1Dpen/Crim1^tm1.1Dpen
• Genetic Background: either: (B6.129P2(129S7)-Crim1^tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)

renal/urinary system

abnormal renal glomerulus morphology ( J:187855 )

renal hypoplasia ( J:187855 )

homeostasis/metabolism

edema ( J:187855 )

• in some mice, noted as early as E14.5

integument

bleb ( J:187855 )

• peridermal blebbing at E12.5 and E13.5

limbs/digits/tail

syndactyly ( J:187855 )

• mild at E13.5

vision/eye

microphthalmia ( J:187855 )

• eye hypoplasia from E13.5

Genotype
MGI:5438634

hm3

• Allelic Composition: Crim1^tm1.1Dpen/Crim1^tm1.1Dpen
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1

mortality/aging

lethality, incomplete penetrance ( J:187855 )