Phenotypes associated with this allele

• Allele Symbol: Usp46^CS
• Allele Name: CS
• Allele ID: MGI:5438646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp46^CS/Usp46^CS	B6.CS-Usp46^CS	MGI:5438673

Genotype
MGI:5438673

hm1

• Allelic Composition: Usp46^CS/Usp46^CS
• Genetic Background: B6.CS-Usp46^CS

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal depression-related behavior ( J:150364 , J:187828 )

• in tail suspension and forced swim tests, mice exhibit low immobility time compared with C57BL/6 mice (J:150364)

• immobility time is insensitive to imipramine (J:150364)

• however, a Usp46-expressing transgene rescues sensitivity to the anti-immobility effect of imipramine (J:150364)

• in a tail suspension test, mice exhibit shorter immobility time compared with wild-type mice (J:187828)

• in a tail suspension test, nitrazepam-treated mice exhibit a dose-dependent increase in immobility time unlike in wild-type mice (J:187828)

• however, flumazenil blocks the effect of nitrazepam (J:187828)

abnormal anxiety-related response ( J:150364 )

• in a light dark box test, mice spend less time in the dark compartment compared with C57BL/6 mice

• however, defecation was normal

improved righting response ( J:150364 )

• mice exhibit faster righting reflex that is insensitive to muscimol administration compared with C57BL/6 mice

• however, a Usp46-expressing transgene rescues sensitivity to the anti-righting reflex effect of muscimol

abnormal nest building behavior ( J:150364 )

• mice use less amounts of nest material compared with C57BL/6 mice

• however, a Usp46-expressing transgene rescues nest building