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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp46Gt(pU17)1Imeg
gene trap 1, Institute of Molecular Embryology and Genetics
MGI:5438668
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg B6.Cg-Usp46Gt(pU17)1Imeg MGI:5439483


Genotype
MGI:5439483
hm1
Allelic
Composition		 Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic
Background		 B6.Cg-Usp46Gt(pU17)1Imeg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp46Gt(pU17)1Imeg mutation (0 available); any Usp46 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal depression-related behavior ( J:187828 )
• in a tail suspension test, mice exhibit shorter immobility time compared with wild-type mice
• in a tail suspension test, nitrazepam-treated mice exhibit a dose-dependent increase in immobility time unlike in wild-type mice
• however, flumazenil blocks the effect of nitrazepam




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory