Phenotypes associated with this allele

• Allele Symbol: Fgf10^{tm1.1(cre/ERT2)Sbel}
• Allele Name: targeted mutation 1.1, Saverio Bellusci
• Allele ID: MGI:5438701
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf10^tm1.1(cre/ERT2)Sbel/Fgf10^tm1.1(cre/ERT2)Sbel	involves: C57BL/6	MGI:5438774
cn2	Fgf10^tm1.1(cre/ERT2)Sbel/Fgf10^tm1Sms Gt(ROSA)26Sor^tm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5438775

Genotype
MGI:5438774

hm1

• Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^{tm1.1(cre/ERT2)Sbel}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

absent lung buds ( J:187831 )

• embryos display complete lung agenesis by E12.5

limbs/digits/tail

absent limbs ( J:187831 )

• embryos display complete limb agenesis by E12.5

digestive/alimentary system

cecal atresia ( J:187831 )

• observed at E12.5

colon atresia ( J:187831 )

• embryos show colonic atresia by E12.5

Genotype
MGI:5438775

cn2

• Allelic Composition: Fgf10^{tm1.1(cre/ERT2)Sbel}/Fgf10^tm1Sms; Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

respiratory system

abnormal lung bud morphology ( J:187831 )

• with tamoxifen administration to dams from E8.5 to 14.5, embryonic lungs display abnormal shape and simplified branching (reduced number of terminal buds in accessory lobe as example)

limbs/digits/tail

interdigital webbing ( J:187831 )

• with tamoxifen administration to dams from E8.5 to 14.5, webbed digits are observed at level of forelimbs in embryos

digestive/alimentary system

abnormal cecum development ( J:187831 )

• with tamoxifen administration to dams from E8.5 to 14.5, cecum length is decreased in embryos relative to controls