All Phenotypes Kdm6a<tm1a(EUCOMM)Jhha> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm6a^{tm1a(EUCOMM)Jhha}
targeted mutation 1a, Jacob H Hanna
MGI:5438704

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm6a^{tm1a(EUCOMM)Jhha}/Y Tg(Pgk1-cre)1Lni/0	involves: 129 * BALB/c * C57BL/6 * DBA	MGI:5438706
cn2	Kdm6a^{tm1a(EUCOMM)Jhha}/Kdm6a^{tm1b(EUCOMM)Jhha} Tg(Pgk1-cre)1Lni/0	involves: 129 * BALB/c * C57BL/6 * DBA	MGI:5438707

Allelic Composition	Kdm6a^{tm1a(EUCOMM)Jhha}/Y Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129 * BALB/c * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{tm1a(EUCOMM)Jhha} mutation (0 available); any Kdm6a mutation (40 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:186686 )

• virtually all embryos die at E9.5 with only a single mouse surviving

embryo

embryonic growth retardation ( J:186686 )

• severe

growth/size/body

embryonic growth retardation ( J:186686 )

• severe

Allelic Composition	Kdm6a^{tm1a(EUCOMM)Jhha}/Kdm6a^{tm1b(EUCOMM)Jhha} Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: 129 * BALB/c * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^{tm1a(EUCOMM)Jhha} mutation (0 available); any Kdm6a mutation (40 available)
Kdm6a^{tm1b(EUCOMM)Jhha} mutation (0 available); any Kdm6a mutation (40 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:186686 )

• at E11.5

nervous system

open neural tube ( J:186686 )

• severe closure defect at E11.5

embryo

open neural tube ( J:186686 )

• severe closure defect at E11.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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