Phenotypes associated with this allele

• Allele Symbol: Tyk2^tm1Biat
• Allele Name: targeted mutation 1, Biomodels Austria
• Allele ID: MGI:5438711
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyk2^tm1Biat/Tyk2^tm1Biat	B6NCrl.129P2-Tyk2^tm1Biat	MGI:5438773
hm2	Tyk2^tm1Biat/Tyk2^tm1Biat	involves: 129P2/OlaHsd * C57BL/6	MGI:5438712

Genotype
MGI:5438773

hm1

• Allelic Composition: Tyk2^tm1Biat/Tyk2^tm1Biat
• Genetic Background: B6NCrl.129P2-Tyk2^tm1Biat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:187818 )

• mice infected with VSV exhibit increased mortality compared with wild-type mice

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:187818 )

• mice infected with EMCV exhibit increased mortality compared with wild-type mice

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:187818 )

• mice infected with VSV exhibit increased mortality compared with wild-type mice

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:187818 )

• mice infected with EMCV exhibit increased mortality compared with wild-type mice

Genotype
MGI:5438712

hm2

• Allelic Composition: Tyk2^tm1Biat/Tyk2^tm1Biat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

increased susceptibility to viral infection induced morbidity/mortality ( J:65408 )

• in mice infected with vesicular stomatitis virus

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:116703 )

• following infection with murine cytomegalovirus, all mice die by day 7 of infection at a low dose and by day 5 of infection at a high dose whereas all wild-type mice survive infection with a low dose and 50% die by day 5 and 70% by day 7 when infected with a high dose

immune system

decreased macrophage nitric oxide production ( J:65408 )

• type I IFN and LPS-induced

decreased interferon-gamma secretion ( J:65408 )

• in con A-activated spleen cells

abnormal response to infection ( J:116703 )

• MCMV replication in macrophages is increased greater than 1000-fold compared to that in wild-type macrophages

• following infection with MCMV, nitric oxide production is impaired

• however, treatment with IFN-beta can still inhibit virus replication

increased susceptibility to viral infection induced morbidity/mortality ( J:65408 )

• in mice infected with vesicular stomatitis virus

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:116703 )

• following infection with murine cytomegalovirus, all mice die by day 7 of infection at a low dose and by day 5 of infection at a high dose whereas all wild-type mice survive infection with a low dose and 50% die by day 5 and 70% by day 7 when infected with a high dose

increased susceptibility to Herpesvirales infection ( J:116703 )

• following infection with murine cytomegalovirus, all mice die by day 7 of infection at a low dose and by day 5 of infection at a high dose whereas all wild-type mice survive infection with a low dose and 50% die by day 5 and 70% by day 7 when infected with a high dose

increased susceptibility to Riboviria infection ( J:65408 )

• mice infected with vesicular stomatitis virus (VSV) exhibit increased mortality compared with wild-type mice

• mice infected with lymphocytic choriomeningitis virus (LCMV) exhibit 3- to 10-fold reduction of cytotoxic T lymphocyte activity compared with wild-type mice

• mice infected with vaccinia virus (VV) exhibit increased viral replication in the spleen compared with wild-type mice

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:116703 )

• following infection with murine cytomegalovirus, nitric oxide production is impaired

decreased macrophage nitric oxide production ( J:65408 )

• type I IFN and LPS-induced

hematopoietic system

decreased macrophage nitric oxide production ( J:65408 )

• type I IFN and LPS-induced