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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tyk2tm3.1Biat
targeted mutation 3.1, Biomodels Austria
MGI:5438771
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tyk2tm3.1Biat/Tyk2tm3.1Biat B6NCrl.129P2(C)-Tyk2tm3.1Biat MGI:5438772


Genotype
MGI:5438772
hm1
Allelic
Composition		 Tyk2tm3.1Biat/Tyk2tm3.1Biat
Genetic
Background		 B6NCrl.129P2(C)-Tyk2tm3.1Biat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyk2tm3.1Biat mutation (1 available); any Tyk2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:187818 )
• mice infected with VSV exhibit increased mortality compared with wild-type mice
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:187818 )
• mice infected with EMCV exhibit increased mortality compared with wild-type mice

mortality/aging
increased susceptibility to Riboviria infection induced morbidity/mortality ( J:187818 )
• mice infected with VSV exhibit increased mortality compared with wild-type mice
increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:187818 )
• mice infected with EMCV exhibit increased mortality compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory