Phenotypes associated with this allele

• Allele Symbol: Il17a/Il17f^tm1.1Impr
• Allele Name: targeted mutation 1.1, Immo Prinz
• Allele ID: MGI:5438791
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17a/Il17f^tm1.1Impr/Il17a/Il17f^tm1.1Impr	involves: C57BL/6	MGI:5438820

Genotype
MGI:5438820

hm1

• Allelic Composition: Il17a/Il17f^tm1.1Impr/Il17a/Il17f^tm1.1Impr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:187400 , J:189794 )

N • unlike Il17a^tm1Yiw Il17f^tm1Yiw double homozygotes, mice show no opportunistic infection (J:187400)

N • irradiated mice reconstituted with the bone marrow of Trdc^tm1Mal or C57BL/6 mice exhibit normal numbers of IL17+ alpha beta TCR lymphocytes (J:187400)

N • mice infected with Plasmodium berghei ANKA exhibit normal development of experimental cerebral malaria (J:189794)

increased T cell proliferation ( J:187400 )

• of CCR6-CD27+ gamma delta T effector cells in the thymus

• however, proliferation in the periphery is normal

absent gamma-delta T cells ( J:187400 )

• of IL17+ cells in irradiated mice reconstituted with the bone marrow of Trdc^tm1Mal or C57BL/6 mice

increased gamma-delta T cell number ( J:187400 )

• CCR6+CD27- gamma delta T effector cells due to a moderately higher turnover

• however, mice exhibit normal numbers of CCR6-CD27+ gamma delta T cells

abnormal effector T cell morphology ( J:187400 )

• increased CCR6+CD27- gamma delta T effector cells due to a moderately higher turnover

decreased interleukin-17 secretion ( J:187400 )

• of IL17a and IL17f in CD4+ T cells and gamma delta T cells

hematopoietic system

increased T cell proliferation ( J:187400 )

• of CCR6-CD27+ gamma delta T effector cells in the thymus

• however, proliferation in the periphery is normal

absent gamma-delta T cells ( J:187400 )

• of IL17+ cells in irradiated mice reconstituted with the bone marrow of Trdc^tm1Mal or C57BL/6 mice

increased gamma-delta T cell number ( J:187400 )

• CCR6+CD27- gamma delta T effector cells due to a moderately higher turnover

• however, mice exhibit normal numbers of CCR6-CD27+ gamma delta T cells

abnormal effector T cell morphology ( J:187400 )

• increased CCR6+CD27- gamma delta T effector cells due to a moderately higher turnover

cellular

increased T cell proliferation ( J:187400 )

• of CCR6-CD27+ gamma delta T effector cells in the thymus

• however, proliferation in the periphery is normal