Phenotypes associated with this allele

• Allele Symbol: Prox1^tm1.1Fuma
• Allele Name: targeted mutation 1.1, Fumio Matsuzaki
• Allele ID: MGI:5438824
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prox1^tm1.1Fuma/Prox1^tm1.1Fuma Tg(Camk2a-cre)20Kmik/0	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5438958
cn2	Prox1^tm1.1Fuma/Prox1^tm1.1Fuma Tg(Camk2a-cre/ERT2)2Gsc/0	involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:5438959

Genotype
MGI:5438958

cn1

• Allelic Composition: Prox1^tm1.1Fuma/Prox1^tm1.1Fuma; Tg(Camk2a-cre)20Kmik/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:187615 )

• the dentate gyrus is small due to apoptosis from leaky cre expression

• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells

abnormal hippocampus CA4 region morphology ( J:187615 )

• at P28, mossy cells are reduced in the hilus compared to in control mice

abnormal hippocampus granule cell morphology ( J:187615 )

• the dentate gyrus consists completely of CA3 pyramidal cells with no granule cells

Genotype
MGI:5438959

cn2

• Allelic Composition: Prox1^tm1.1Fuma/Prox1^tm1.1Fuma; Tg(Camk2a-cre/ERT2)2Gsc/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

nervous system

abnormal dentate gyrus morphology ( J:187615 )

• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice

abnormal hippocampus CA4 region morphology ( J:187615 )

• at P28, mossy cells are reduced in the hilus compared to in control mice

abnormal hippocampus granule cell morphology ( J:187615 )

• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice